By vgreene, 11 January, 2021 Safety Update COVID 19 Convalescent Plasma in 20 000 Hospitalized Patients pre print Mayo Clin Proc article
By vgreene, 11 January, 2021 Significantly less pts developed severe respiratory dz w convalescent plasma 16 vs 31 RR 0 52 95 CI 0 29 0 94 lower rates of dz progression w infusions w donor titers 1 3200 73 relative risk reduction no correlation w outcomes based on recipient antibody
By vgreene, 11 January, 2021 Randomized double blind placebo controlled study 160 pts mean age 77 2y w mild COVID 19 received 250 mL convalescent plasma w IgG titer 1 1000 n 80 or placebo n 80 w in 72h after sx onset
By vgreene, 11 January, 2021 Study considerations randomized double blind early termination in October 2020 due to epidemic containment in Argentina small sample size possibly underpowered
By vgreene, 11 January, 2021 KEY FINDINGS early admin of high titer convalescent plasma reduced COVID 19 progression in older adults w mild dz
By vgreene, 11 January, 2021 Early High Titer Plasma Therapy to Prevent Severe Covid 19 in Older Adults
By vgreene, 11 January, 2021 However a recent preliminary laboratory study published on the preprint server bioRxiv a study which has not been reviewed by outside experts finds that the Pfizer COVID 19 vaccine appears to provide protection against both the South African U K variants
