By switaschek, 7 July, 2020 Reserve pegloticase only for pts w/ SU above target on all other tx and either ≥2 flares/yr or tophi not resolved, per ACR;1 per EULAR, reserve for pts w/ severe crystal-proven tophaceous gout and poor QOL who fail all other tx2
By switaschek, 7 July, 2020 Consider combo-tx (XOI + uricosuric) in pts failing 2nd-line tx (whether second XOI or uricosuric)2
By switaschek, 7 July, 2020 Consider switch to alt XOI in pts w/ SU not at target, ≥2 flares/yr, or tophi not resolved, per ACR; switch to uricosuric after initial XOI failure an option, per EULAR