By vgreene, 29 June, 2020 Clinical deterioration rate lower in colchicine group (2% vs 14%); mean event-free survival time greater in colchicine group (20.7 vs 18.6 days); no difference in max high-sensitivity cardiac troponin levels or peak CRP levels; overall adverse events simi
By vgreene, 29 June, 2020 Prospective, open-label, multicenter, randomized study; 105 hospitalized pts (median age 64y) w/ confirmed COVID-19 tx w/ colchicine 1.5 mg x1 then 0.5 mg after 60min, then 0.5 mg bid (n=55) + SOC or SOC only (n=50) for up to 3wk; most pts received CQ/HCQ
By vgreene, 29 June, 2020 Pilot Prospective Open Single arm Multicentre Study on Off label Use of Tocilizumab in Patients With Severe COVID 19
By vgreene, 29 June, 2020 Study considerations: single-arm, open-label study; small sample size; heterogeneous antiviral tx and TCZ admin routes; SC dose based on PK in RA pts; timing of tx; limited f/u
By vgreene, 29 June, 2020 Overall mortality 11% (no difference btwn routes); oxygenation and D-dimer and CRP levels significantly improved over time; TCZ w/in 6 days from admission assoc w/ incr likelihood of survival (HR 2.2, 95% CI 1.3-6.7); no severe ADRs reported
By vgreene, 29 June, 2020 Prospective, open-label, single-arm, multicenter study; 63 hospitalized pts (mean age 62.6 y) w/ confirmed severe COVID-19 and markedly abnormal pro-inflammatory profile received TCZ 8 mg/kg IV (n=34) or 324 mg SC (n=29) x1 dose, 83% received 2nd dose w/
By vgreene, 29 June, 2020 ART should be initiated in all infants children w HIV infxn AI Recommend rapid ART initiation immediately or w in days of dx accompanied by adherence discussion subsequent adherence support
By vgreene, 29 June, 2020 ART should be initiated in all infants children w HIV infxn AI Recommend rapid ART initiation immediately or w in days of dx accompanied by adherence discussion subsequent adherence support
By vgreene, 29 June, 2020 ART should be initiated in all infants children w HIV infxn AI accompanied by adherence discussion subsequent adherence support Rapid ART initiation immediately or w in days of dx recommended except in pts w cryptococcal meningitis disseminated MAC or TB