By vgreene, 25 June, 2020 Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial; full-text JAMA Netw Open article
By vgreene, 25 June, 2020 Dexamethasone in Hospitalized Patients With COVID 19 Preliminary Report RECOVERY
By vgreene, 25 June, 2020 Study considerations: randomized but open-label; incl limited numbers of peds, pregnant, and breastfeeding pts; excl pts w/ contraindication or definitive indication for dexamethasone
By vgreene, 25 June, 2020 Hospital stay shorter w DEX vs SOC 12 vs 13 days w greater probability of discharge w in 28 days RR 1 10 95 CI 1 03 1 17 and lower risk of progression to invasive mech vent RR 0 77 95 CI 0 62 0 95
By vgreene, 25 June, 2020 28 day all cause mortality lower in DEX vs SOC group RR 0 83 95 CI 0 74 to 0 93 pre specified subgroup analysis showed greater benefit in mech vent pts 36 RR reduction and non intubated pts on O2 18 RR reduction but no benefit in pts not needing resp supp