By vgreene, 19 May, 2020 Risk factors for severe illness: Age is strong risk factor for severe illness, complications, and death. Among >44,000 confirmed cases in China, case fatality rate was highest among older persons: ≥80 yo: 14.8%, 70–79 yo: 8.0%, 60–69 yo: 3.6%, 50–59 yo: 1
By vgreene, 19 May, 2020 Clinical progression: Among those who developed severe dz, median time to dyspnea was 5-8 days; median time to ARDS was 8-12 days, median time to ICU admission was 10-12 days. Be aware that some pts may rapidly deteriorate 1wk after illness onset. Among a
By vgreene, 19 May, 2020 Illness severity: ranges from mild to critical. According to cohort study (N>44,000): 81% mild to mod (mild sx up to mild pneumonia); 14% severe (dyspnea, hypoxia, or >50% lung involvement on imaging); and 5% critical (resp failure, shock, or multiorgan s
By vgreene, 19 May, 2020 Asymptomatic/pre-symptomatic transmission: Increasing numbers of epidemiologic studies have documented SARS-CoV-2 transmission during pre-symptomatic incubation period. Large quantities of viral RNA and viable virus have been cultured from pts w/ asymptom
By vgreene, 19 May, 2020 Asymptomatic/pre-symptomatic infxn: since asymptomatic pts not routinely tested, prevalence of asymptomatic infxn and detection of pre-symptomatic infxn not well understood. In 1 study, 13% of RT-PCR-confirmed cases in children were asymptomatic. Another