(BMJ)—An 18-mo girl presented w/ a 5-day hx of fever (≥40°C), w/ painful neck swelling. No respiratory sx. Exam: large, tender cervical nodes; localized redness and edema over previously healed bacillus Calmette-Guérin inoculation site; otherwise normal. Labs: elevated CRP and erythrocyte sedimentation rate. UA normal. What is the dx?
Incomplete Kawasaki disease
Lupus vulgaris
Cellulitis
Mononucleosis
Disseminated tuberculosis
You are correct. Incomplete Kawasaki dz (IKD) was suggested by inflammation over a previously healed bacillus Calmette-Guérin scar (BCG-itis), 5 days of fever, cervical lymphadenopathy, and raised inflammatory markers. Dx criteria for classic Kawasaki dz are fever for ≥5 days, w/ ≥4 of the following: bilateral nonsuppurative conjunctivitis, oral mucosal injection, polymorphous rash, cervical lymphadenopathy, and indurative edema of the extremities, followed by desquamation. Consider IKD if these criteria are not fully met, but ≥1 of the following are present: BCG-itis, raised inflammatory markers, leukocytosis, thrombocytosis, hypoalbuminemia, anemia, increased LFTs, and/or pyuria. As BCG-itis occurs early in the course of Kawasaki dz, it is a useful sign for the early dx of pts w/ IKD. This pt’s echocardiogram showed mildly dilated coronary arteries. After she was treated w/ intravenous immunoglobulin, her fever resolved and inflammatory markers improved. The coronary artery dilatation resolved w/in 3mo.

BMJ 2020;368:l6823
By vgreene, 28 January, 2020
By vgreene, 28 January, 2020
By vgreene, 28 January, 2020
By vgreene, 28 January, 2020
By vgreene, 28 January, 2020