By vgreene, 9 January, 2020
(BMJ)—A previously healthy 32-yo man presented w/ a 3-mo hx of multiple mildly pruritic lesions on his head, chest, back, left forearm, and legs. No fever/malaise/HA/arthralgia. Social hx: unprotected sexual intercourse w/ several partners. Exam: multiple annular concentric plaques w/ slightly raised scaly borders. Lab tests confirmed the dx. What is it?
Actinic granuloma
Granuloma annulare
Subacute cutaneous lupus erythematosus
Tinea corporis
Secondary syphilis
You are correct. The lesions are typical of annular secondary syphilis (annular, arcuate, or gyrate patterns w/ delicate, slightly raised, infiltrated, or scaling ridges), and a positive rapid plasma reagin test confirmed it. During the course of untreated secondary syphilis, annular lesions may appear and disappear; when they reappear, the lesions are usually larger, darker, and more discrete. A generalized nonpruritic maculopapular rash is more common than an annular rash in secondary syphilis. Pt was treated w/ IM penicillin G benzathine, and the lesions resolved after 3wk, w/ only slight hyperpigmentation visible.

BMJ 2019;367:l5512