By vgreene, 27 September, 2017 CA tx In 1 study of CA pts treated w IV irinotecan or docetaxel concomitant administration of cannabis herbal tea didn t influence irinotecan or docetaxel exposure or clearance 1
By vgreene, 27 September, 2017 ADHD stimulants There s substantial evidence S that ADHD stimulant tx during adolescence is not a risk factor for problem cannabis use development 3
By vgreene, 27 September, 2017 CNS depressants Additive effects may occur when cannabinoids are taken w alcohol or other CNS depressants
By vgreene, 27 September, 2017 Drugs metabolized by P450 system Cannabinoids interact w hepatic cytochrome P450 enzymes 1 2 substances that inhibit or induce P450 enzymes may alter drug adverse effects or efficacy THC CBD and cannabinol inhibition induction studies on major human CYP 4
By vgreene, 27 September, 2017 Depression in MS Limited evidence L that nabilone no longer available in the U S nabiximols and dronabinol are ineffective for darr depressive sx in MS 1
By vgreene, 27 September, 2017 Sleep disturbance in MS Moderate evidence M that cannabinoids primarily nabiximols improve short term sleep outcomes 1
By vgreene, 27 September, 2017 Bladder dysfxn in MS Nabiximols is probably effective for darr of bladder voids day at 10wk but is of unknown efficacy for darr overall bladder sx conflicting studies THC and oral cannabis extract are probably ineffective for bladder complaints 2
By vgreene, 27 September, 2017 Tremor in MS THC and oral cannabis extract are probably ineffective nabiximols is possibly ineffective 2
By vgreene, 27 September, 2017 Central pain or painful spasms in MS Oral cannabis extract is effective for darr central pain and THC or nabiximols is probably effective for MS related pain or painful spasms but smoked marijuana is of unclear efficacy for darr pain 2
By vgreene, 27 September, 2017 MS spasticity nbsp nbsp Evidence for effectiveness of oral cannabinoids is conclusive or substantial C S for improving pt reported spasticity sx and is limited L for clinician measured spasticity per NAS 1 nbsp nbsp AAN concluded oral cannabis extract dar
