(BMJ)—An 81-yo man w/ insulin-treated T2DM presented w/ sudden onset of R arm pain, redness, & swelling that began in his hand 1 day prior while he was fishing. Exam: hypotension, tachycardia, low-grade fever; R arm purple, tender, +crepitus. Labs: low WBC, high CK. What is the dx?
Necrotizing fasciitis
Bullous pemphigoid
Arterial embolus
Polyarteritis nodosa
Deep vein thrombosis
You are correct. Worsening pain, purplish red skin discoloration, reddish blue bullae w/ serohemorrhagic fluid, tissue crepitation (indicating tissue gas), & s/sx of systemic toxicity strongly suggest a necrotizing soft tissue infxn & exclude conditions such as venous thrombosis, autoimmune skin dz, & uncomplicated cellulitis. The pt underwent urgent surgical exploration that revealed muscle necrosis. Cx was positive for Clostridium septicum. Spontaneous forms of clostridial myonecrosis are extremely rare but can manifest in pts w/ malignancy, immunosuppression, &/or DM. These forms can have a fulminant evolution & must be evaluated w/in hrs to increase chances of survival. After an initial improvement following surgery, this pt later died of multiple organ failure.
By vgreene, 29 August, 2016