Chest
CHEST 2024: GERD linked to better in-hospital outcomes for COPD patients
October 15, 2024
COPD patients with concomitant GERD had better in-hospital outcomes, including lower mortality rates and reduced risks of several complications, despite the traditionally perceived exacerbating effects of GERD on COPD symptoms. These findings were shared at the recent CHEST 2024 annual meeting.
In this retrospective analysis, researchers used the National Readmission Database from 2017-2020 and identified hospitalized adults with a primary diagnosis of COPD (N=3,798,952), with patients presenting with GERD categorized as the exposure group (n=1,024,665). Patients with associated GERD demonstrated the following:
- Lower mortality rate (adjusted odds ratio [aOR], 0.717; p < 0.001)
- Reduced risks for acute respiratory failure (aOR, 0.915), mechanical ventilation (aOR, 0.907), acute kidney injury (aOR, 0.877), septic shock (aOR, 0.731), and acute heart failure (aOR, 0.762)
- Increased risk of 30-day readmission (aOR, 1.08)
- Longer (but clinically insignificant) hospital stays and lower total hospital charges
Source:
Nasibul Alam, A B M; et al. (2024, October). CHEST. Understanding the impact of GERD on COPD hospitalization outcomes: Insights from a nationwide analysis. https://journal.chestnet.org/article/S0012-3692(24)03703-6/fulltext
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