Mysoline

Adult Dosing .

Dosage forms:  TAB: 50 mg, 250 mg

seizure disorder

[250 mg PO tid-qid]

Start: 100-125 mg PO qhs x3 days, then 100-125 mg PO bid x3 days, then 100-125 mg PO tid x3 days, then 250 mg PO tid-qid; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

essential tremor (off-label)

[50-250 mg PO qhs]

Start: 12.5-25 mg PO qhs, incr. by 12.5-25 mg/day qwk; Max: 750 mg/day; Info: divide doses >250 mg/day; taper dose gradually to D/C

renal dosing

[adjust dose frequency]

CrCl 50-89: give usual dose no more frequently than q12h; CrCl 10-50: give usual dose no more frequently than q12-24h; CrCl <10: give usual dose q24h

HD: give usual dose q24h, on dialysis days admin. after dialysis; no supplement; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 50 mg, 250 mg

seizure disorder

[neonates]

Dose: 12-20 mg/kg/day PO divided bid-qid; Start: 15-20 mg/kg/dose PO x1; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

[<8 yo]

Dose: 10-25 mg/kg/day PO divided tid-qid; Start: 50 mg PO qhs x3 days, then 50 mg PO bid x3 days, then 100 mg PO bid x3 days; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

[8 yo and older]

Dose: 250 mg PO tid-qid; Start: 100-125 mg PO qhs x3 days, then 100-125 mg PO bid x3 days, then 100-125 mg PO tid x3 days, then 250 mg PO tid-qid; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

renal dosing

[adjust dose frequency]

CrCl 50-89: give usual dose no more frequently than q12h; CrCl 10-50: give usual dose no more frequently than q12-24h; CrCl <10: give usual dose q24h

HD: give usual dose q24h, on dialysis days admin. after dialysis; no supplement; PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised