Select a medication above to begin.
pimozide
generic
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: TAB: 1 mg, 2 mg
Tourette syndrome, severe
- [2-10 mg/day PO divided qd-bid]
- Start: 1-2 mg/day PO divided qd-bid, may incr. dose qod; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >4 mg/day; in CYP2D6 poor metabolizers, may incr. dose q14 days up to max 4 mg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
schizophrenia (off-label)
- [2-4 mg/day PO divided qd-bid]
- Start: 0.5-2 mg/day PO divided qd-bid, may incr. dose qod; Max: 10 mg/day; Info: perform CYP2D6 genotyping if doses >4 mg/day; in CYP2D6 poor metabolizers, may incr. dose q14 days up to max 4 mg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 1 mg, 2 mg
Tourette syndrome, severe
- [12 yo and older]
- Dose: 1-10 mg/day PO divided qd-bid; Start: 0.05 mg/kg/dose PO qhs, may incr. dose q3 days; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >0.05 mg/kg/day; in CYP2D6 poor metabolizers, may incr. dose q14 days up to max 0.05 mg/kg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised