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Daxxify (daxibotulinumtoxinA-lanm)
daxibotulinumtoxinA
Black Box Warnings .
Distant Spread of Toxin Effect
effects of all botulinum toxin products may spread beyond tx area to produce sx consistent w/ botulinum toxin; sx incl. asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties; life-threatening swallowing and breathing difficulties can occur; deaths reported; sx may occur hours to weeks after injection; risk greatest in children treated for spasticity but can occur in adults, esp. if underlying risk factors; in unapproved uses, incl. spasticity in children, and in approved indications, spread of effect reported at doses comparable to or lower than max recommended total dose
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = daxibotulinumtoxinA-lanm
glabellar lines, moderate-severe
- [40 units IM divided equally in 5 sites x1]
- Info: may repeat no more frequently than q3mo
cervical dystonia
- [125-250 units IM divided among affected muscles x1]
- Info: adjust dose in 50-75 unit increments; may repeat no more frequently than q3mo
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.