nitroglycerin

Adult Dosing .

Dosage forms:  ER CAP: 2.5 mg, 6.5 mg, 9 mg; SL TAB: 0.3 mg, 0.4 mg, 0.6 mg; SPRAY: 0.4 mg per actuation; INJ: various

angina, acute

[sublingual tab form]

Dose: 0.3-0.6 mg SL q5min; Max: 3 doses w/in 15min

[translingual spray form]

Dose: 1-2 actuations SL q5min prn; Max: 3 actuations w/in 15min

[IV form]

Dose: 5-100 mcg/min IV; Start: 5 mcg/min IV, may incr. by 5 mcg/min q3-5min until response or 20 mcg/min IV; if no response, then may incr. by 10-20 mcg/min q3-5min; Info: use if unresponsive to SL NTG and beta blockers

angina prophylaxis

[sublingual tab form]

Dose: 0.3-0.6 mg SL x1; Start: 5-10 min before strenuous activity

[translingual spray form]

Dose: 1-2 actuations SL x1; Start: 5-10min before strenuous activity

[extended-release form]

Dose: 2.5-9 mg ER PO tid-qid; Start: 2.5-6.5 mg ER PO tid-qid; Max: 26 mg ER PO qid

HTN

[5-100 mcg/min IV]

Start: 5 mcg/min IV, may incr. by 5 mcg/min q3-5min until response or 20 mcg/min IV; if no response, then may incr. by 10-20 mcg/min q3-5min

heart failure, post-MI

[5-100 mcg/min IV]

Start: 5 mcg/min IV, may incr. by 5 mcg/min q3-5min until response or 20 mcg/min IV; if no response, then may incr. by 10-20 mcg/min q3-5min

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

HTN (off-label)

[1-5 mcg/kg/min IV]

Start: 0.25-0.5 mcg/kg/min, incr. 0.5-1 mcg/kg/min q3-5min until response; Max: 20 mcg/kg/min

heart failure (off-label)

[1-5 mcg/kg/min IV]

Start: 0.25-0.5 mcg/kg/min, incr. 0.5-1 mcg/kg/min q3-5min until response; Max: 20 mcg/kg/min

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]