oxacillin

Adult Dosing .

Dosage forms:  INJ

infections, bacterial

[mild-moderate infection]

Dose: 250-500 mg IM/IV q4-6h

[severe infection]

Dose: 1 g IM/IV q4-6h; Info: give 2 g IV q4h for MSSA infections or catheter-assoc. bacteremia

endocarditis

[native valve]

Dose: 2 g IV q4h x6wk; Info: give x2wk if uncomplicated, right-sided infection; refer to AHA guidelines

[prosthetic valve]

Dose: 2 g IV q4h for at least 6wk; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines

pneumonia, community-acquired

[2 g IV q4h for at least 5 days]

Info: for inpatient tx

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial

[neonates 0-7 days old, <2 kg]

Dose: 50 mg/kg/day IM/IV divided q12h

[neonates 0-7 days old, >2 kg]

Dose: 75 mg/kg/day IM/IV divided q8h

[neonates >7 days old, <1.2 kg]

Dose: 50 mg/kg/day IM/IV divided q12h

[neonates >7 days old, 1.2-2 kg]

Dose: 75 mg/kg/day IM/IV divided q8h

[neonates >7 days old, >2 kg]

Dose: 100 mg/kg/day IM/IV divided q6h

[1 mo-12 yo]

Dose: 100-200 mg/kg/day IM/IV divided q4-6h; Max: 12 g/day

endocarditis

[native valve]

Dose: 200 mg/kg/day IV divided q4-6h x4-6wk; Max: 12 g/day; Info: may give w/ gentamicin gram positive synergy x3-5 days; refer to AHA guidelines

[prosthetic valve]

Dose: 200 mg/kg/day IV divided q4-6h for at least 6wk; Max: 12 g/day; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines

community-acquired pneumonia, severe bacterial (off-label)

[>3 mo]

Dose: 150-200 mg/kg/day IM/IV divided q6-8h x10 days; Max: 12 g/day; Info: may switch to PO regimen when possible to complete course

renal dosing

[adjust dose amount]

CrCl <10: use lower end of dosing range

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[not defined]