Zarontin

Adult Dosing .

Dosage forms:  CAP: 250 mg; SOL: 250 mg per 5 mL

seizures, absence

[250-750 mg PO bid]

Start: 250 mg PO bid, may incr. by 250 mg/day q4-7 days; Max: 1.5 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

renal dosing

[see below]

CrCl <10: decr. usual dose by 25%

HD: no adjustment, on dialysis days admin. after dialysis; no supplement; PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  CAP: 250 mg; SOL: 250 mg per 5 mL

seizures, absence

[3-6 yo]

Dose: 20 mg/kg/day PO divided bid; Start: 250 mg PO qd, may incr. by 250 mg/day q4-7 days; Max: 1.5 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

[6 yo and older]

Dose: 20 mg/kg/day PO divided bid; Start: 250 mg PO bid, may incr. by 250 mg/day q4-7 days; Max: 1.5 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised