hydrocortisone

Adult Dosing .

Dosage forms:  TAB: 5 mg, 10 mg, 20 mg

adrenal insufficiency, chronic

[25-30 mg/day PO divided bid]

Info: give w/ food or milk; taper dose gradually to D/C

corticosteroid-responsive conditions

[20-240 mg/day PO divided bid-qid]

Info: dose, frequency varies by condition; give w/ food or milk; taper dose gradually to D/C if high dose or long-term use

congenital adrenal hyperplasia, maintenance tx

[15-25 mg/day PO divided bid-tid]

Info: individualize dose based on dz severity and tx response; give w/ food or milk; taper dose gradually to D/C

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 5 mg, 10 mg, 20 mg

adrenal insufficiency, chronic

[8-10 mg/m^2/day PO divided tid]

Info: individualize dose based on dz severity and tx response; use lowest effective dose; may give total daily dose divided bid in older pts; higher doses may be required based on pt age and dz severity or during episodes of acute febrile illness, gastroenteritis, surgery, major trauma; give w/ food or milk; taper dose gradually to D/C

corticosteroid-responsive conditions

[2.5-10 mg/kg/day PO divided tid-qid]

Info: dose, frequency varies by condition; give w/ food or milk; taper dose gradually to D/C if high-dose or long-term use

congenital adrenal hyperplasia

[maintenance tx]

Dose: 10-15 mg/m^2/day PO divided tid; Info: individualize dose based on dz severity and tx response; 20 mg/m^2/day start dose may be required to achieve initial target hormone conc; give w/ food or milk; taper dose gradually to D/C

[moderate stress tx]

Dose: 30-50 mg/m^2/day PO divided tid; Info: individualize dose based on dz severity and tx response; resume maintenance tx once stable; give w/ food or milk

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]