Gleevec

Adult Dosing .

Dosage forms:  TAB: 100 mg, 400 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Ph-positive CML

[chronic phase, newly diagnosed]

Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal

[chronic phase, resistant or intolerant dz]

Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal

[accelerated phase or blast phase, resistant or intolerant dz]

Dose: 600 mg PO qd; Info: may incr. dose to 400 mg PO bid if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal

Ph-positive ALL, relapsed or refractory

[600 mg PO qd]

Info: give w/ meal

myelodysplastic/myeloproliferative dz

[400 mg PO qd]

Info: for pts w/ PDGFR gene re-arrangements; give w/ meal

aggressive systemic mastocytosis

[400 mg PO qd]

Info: for pts w/o D816V c-Kit mutation or unknown c-Kit mutation status; start 100 mg PO qd if eosinophilia-assoc. dz; give w/ meal

hypereosinophilic syndrome and/or CEL

[400 mg PO qd]

Info: start 100 mg PO qd in pts w/ FIP1L1-PDGFR alfa fusion kinase; give w/ meal

dermatofibrosarcoma protuberans

[400 mg PO bid]

Info: for pts w/ unresectable, recurrent, or metastatic dz; give w/ meal

Kit-positive gastrointestinal stromal tumor

[adjuvant tx]

Dose: 400 mg PO qd x3y; Info: give w/ meal

[unresectable or metastatic dz]

Dose: 400 mg PO qd; Max: 400 mg PO bid; Info: give w/ meal

renal dosing

[adjust dose amount]

CrCl 40-59: max 600 mg/day; CrCl 20-39: decr. usual start dose by 50%, max 400 mg/day; CrCl <20: decr. usual dose, amount not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

bilirubin 3.1-10x ULN: decr. usual dose by 25%

Peds Dosing .

Dosage forms:  TAB: 100 mg, 400 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

chronic phase Ph-positive CML, newly diagnosed

[1 yo and older]

Dose: 340 mg/m^2/day PO divided qd-bid; Max: 600 mg/day; Info: give w/ meal

Ph-positive ALL, newly diagnosed

[1 yo and older]

Dose: 340 mg/m^2/dose PO qd; Max: 600 mg/day; Info: part of multi-drug chemo regimen; give w/ meal

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance