mesalamine

Adult Dosing .

Dosage forms:  DR CAP: 400 mg; ER CAP (qid): 500 mg; ER CAP (qd): 0.375 g; DR TAB (tid): 800 mg; DR TAB (qd): 1.2 g

Special Note

[formulation clarification]

Info: mesalamine DR products not interchangeable, do not substitute on a mg to mg basis; each 400 mg DR cap contains elemental iron 2.7 mg

ulcerative colitis, mild-moderate active

[400 mg DR cap]

Dose: 800 mg PO tid x6wk; Info: may open cap, but do not cut/crush/chew/dissolve contents

[500 mg ER cap]

Dose: 1000 mg PO qid x8wk; Info: may open cap, but do not crush/chew/dissolve contents

[1.2 g DR tab]

Dose: 2.4-4.8 g PO qd x8wk; Info: give w/ food; do not cut/crush/chew tab

ulcerative colitis, moderate active

[800 mg DR tab]

Dose: 1600 mg PO tid x6wk; Info: give 1h before or 2h after meals; do not cut/crush/chew tab

ulcerative colitis, maintenance tx

[400 mg DR cap]

Dose: 1600 mg/day PO divided bid-qid; Info: may open cap, but do not cut/crush/chew/dissolve contents

[0.375 g ER cap]

Dose: 1.5 g PO qam

[1.2 g DR tab]

Dose: 2.4 g PO qd; Info: give w/ food; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  DR CAP: 400 mg; DR TAB: 1.2 g

Special Note

[formulation clarification]

Info: mesalamine DR products not interchangeable, do not substitute on a mg to mg basis; each 400 mg DR cap contains elemental iron 2.7 mg

ulcerative colitis, mild-moderate active

[400 mg DR cap, 5 yo and older, 17-32.9 kg]

Dose: 36-71 mg/kg/day divided bid x6wk; Max: 1.2 g/day; Info: may open cap, but do not cut/crush/chew/dissolve contents

[400 mg DR cap, 5 yo and older, 33-53.9 kg]

Dose: 37-61 mg/kg/day divided bid x6wk; Max: 2 g/day; Info: may open cap, but do not cut/crush/chew/dissolve contents

[400 mg DR cap, 5 yo and older, 54-90 kg]

Dose: 27-44 mg/kg/day divided bid x6wk; Max: 2.4 g/day; Info: may open cap, but do not cut/crush/chew/dissolve contents

[1.2 g DR tab, 24-35 kg]

Dose: 1.2 g PO qd; Start: 2.4 g PO qd x8wk; Info: give w/ food; do not cut/crush/chew tab

[1.2 g DR tab, 36-50 kg]

Dose: 2.4 g PO qd; Start: 3.6 g PO qd x8wk; Info: give w/ food; do not cut/crush/chew tab

[1.2 g DR tab, >50 kg]

Dose: 2.4 g PO qd; Start: 4.8 g PO qd x8wk; Info: give w/ food; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised