Select a medication above to begin.
Seroquel XR
quetiapine
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for depression in peds pts
Adult Dosing .
Dosage forms: ER TAB: 50 mg, 150 mg, 200 mg, 300 mg, 400 mg
schizophrenia
- [400-800 mg PO qpm]
- Start: 300 mg PO qpm, then incr. up to 300 mg/day prn; Max: 800 mg/day; Info: start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, manic/mixed
- [400-800 mg PO qpm]
- Start: 300 mg PO qpm x1, then 600 mg PO qpm x1, then may adjust by 200 mg/day prn; Max: 800 mg/day; Info: for acute monotherapy or acute or maint. lithium or valproate adjunct; start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar disorder, acute depressive
- [300 mg PO qpm]
- Start: 50 mg PO qpm x1, then 100 mg PO qpm x1, then 200 mg PO qpm x1, then 300 mg PO qpm; Max: 300 mg/day; Info: start 50 mg PO qpm in elderly or debilitated pts, then incr. by 50 mg/day; give on empty stomach or w/ light meal; do not cut/crush/chew tab; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
major depressive disorder, adjunct tx
- [150-300 mg PO qpm]
- Start: 50 mg PO qpm x2 days, then 150 mg PO qpm x2 days; Max: 300 mg/day; Info: give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
generalized anxiety disorder, tx-resistant (off-label)
- [50-150 mg PO qd]
- Start: 50 mg PO qd, then may incr. by 50 mg/day; Max: 300 mg/day; Info: give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start 50 mg qpm, then incr. by 50 mg/day
Peds Dosing .
- Dosage forms: ER TAB: 50 mg, 150 mg, 200 mg, 300 mg, 400 mg
schizophrenia
- [13-17 yo]
- Dose: 400-800 mg PO qpm; Start: 50 mg PO qpm x1, then 100 mg PO qpm x1, then incr. by 100 mg/day; Max: 800 mg/day; Info: give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
bipolar I disorder, acute manic
- [10-17 yo]
- Dose: 400-600 mg PO qpm; Start: 50 mg PO qpm x1, then 100 mg PO qpm x1, then incr. by 100 mg/day; Max: 600 mg/day; Info: give on empty stomach or w/ light meal; do not cut/crush/chew tab; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: start 50 mg qpm, then incr. by 50 mg/day