Select a medication above to begin.
Exforge
amlodipine/ valsartan
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 5 mg/160 mg, 5 mg/320 mg, 10 mg/160 mg, 10 mg/320 mg
HTN
- [initial tx]
- Dose: 1 tab PO qd; Start: 5 mg/160 mg PO qd, may incr. dose after 1-2wk; Max: 10 mg/320 mg/day; Info: avoid initial tx in elderly pts as lower amlodipine dose not possible w/ fixed-dose combo
- [replacement or add-on tx]
- Dose: 1 tab PO qd; Start: same dose of each component if replacement tx or start combo at lower dose of either component if add-on tx; may incr. dose after 3-4wk; Max: 10 mg/320 mg/day
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: avoid use as initial tx, lower amlodipine dose not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.