Select a medication above to begin.
Daypro
oxaprozin
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 600 mg
osteoarthritis
- [1200 mg PO qd]
- Max: 26 mg/kg/day up to 1800 mg/day; Info: start 600 mg PO qd if low body wt; use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
rheumatoid arthritis
- [1200 mg PO qd]
- Max: 26 mg/kg/day up to 1800 mg/day; Info: start 600 mg PO qd if low body wt; use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
for anti-inflammatory uses (off-label)
- [1200 mg PO qd]
- Max: 26 mg/kg/day up to 1800 mg/day; Info: start 600 mg PO qd if low body wt; use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
pain, mild-moderate (off-label)
- [1200 mg PO qd]
- Max: 26 mg/kg/day up to 1800 mg/day; Info: start 600 mg PO qd if low body wt; use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
renal dosing
- [see below]
- mild-moderate impairment: consider decr. usual dose; severe impairment: avoid use; Alt: start 600 mg qd, max 1200 mg qd; advanced renal dz: avoid use
- HD: avoid use; Alt: start 600 mg qd, max 1200 mg qd; no supplement after dialysis; PD: avoid use; Alt: start 600 mg qd, max 1200 mg qd; no supplement
hepatic dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 600 mg
juvenile idiopathic arthritis
- [6-16 yo, 22-31 kg]
- Dose: 600 mg PO qd; Info: use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
- [6-16 yo, 32-54 kg]
- Dose: 900 mg PO qd; Info: use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
- [6-16 yo, >55 kg]
- Dose: 1200 mg PO qd; Info: use lowest effective dose, shortest effective tx duration; may divide dose bid; give w/ food if GI upset occurs
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance