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trazodone
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 300 mg
major depressive disorder
- [50-100 mg PO bid-tid]
- Start: 25-50 mg PO bid-tid, may incr. by 50 mg/day q3-4 days; Max: 400 mg/day if outpatient, 600 mg/day if inpatient; Info: taper dose gradually to D/C
insomnia (off-label)
- [25-50 mg PO qhs]
- Max: 200 mg/day; Info: often used as adjuvant to SSRI tx; taper dose gradually to D/C if long-term, high-dose use
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.