S. boulardii

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Special Note

[formulation clarification]

Info: uses and doses represent various probiotic-containing products; select proprietary products noted below

[Florastor products]

Info: each capsule or powder pkt contains 250 mg Saccharomyces boulardii lyo CNCM I-745

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

C. difficile infection

[Possibly Effective]

Dose: 500 mg PO bid; Alt: 10-30 billion CFUs PO qd; Info: used w/ antibiotic tx

constipation, peds pts

[Insufficient Evidence]

Dose: 500-750 mg PO qd; Info: for pts 6 mo-12 yo

critical illness (trauma)

[Insufficient Evidence]

Dose: 500 mg PO qid; Alt: 1.5 billion CFUs PO bid

Crohn dz

[Insufficient Evidence]

Dose: 250 mg PO tid; Alt: 1000 mg PO qd

diarrhea, adult pts

[Likely Effective]

Dose: 500 mg PO qid

diarrhea, peds pts

[Likely Effective]

Dose: 150-250 mg PO qd-bid; Alt: 5-10 billion CFUs PO qd; 1750 billion-175 trillion CFUs PO bid

diarrhea, antibiotic-assoc., adult pts

[Possibly Effective]

Dose: 250-500 mg PO bid-qid; Max: 1000 mg/day

diarrhea, antibiotic-assoc., peds pts

[Possibly Effective]

Dose: 250 mg PO qd-bid

diarrhea, HIV/AIDs-related

[Insufficient Evidence]

Dose: 3 g PO qd

diarrhea, rotaviral, peds pts

[Possibly Effective]

Dose: 200-250 mg PO bid

exercise-induced muscle soreness

[Insufficient Evidence]

Dose: 250 mg PO qd; Info: used w/ other probiotics

heart failure

[Insufficient Evidence]

Dose: 1000 mg PO qd

H. pylori infection

[Possibly Effective]

Dose: 100-1000 mg PO qd; Alt: 500 mg PO bid; Info: used w/ standard tx in adult and peds pts

intestinal parasite infection

[Insufficient Evidence]

Dose: 250 mg PO tid; Info: used w/ standard tx

IBS

[Insufficient Evidence]

Dose: 200 billion CFUs PO qd

low birth weight

[Insufficient Evidence]

Dose: 50 mg/kg/dose PO bid; Info: used in preterm infants

necrotizing enterocolitis

[Possibly Effective]

Dose: 100-200 mg/kg/dose PO qd; Info: used in preterm infants

neonatal jaundice

[Insufficient Evidence]

Dose: 250 mg PO qd

small intestinal bacterial overgrowth (SIBO)

[Insufficient Evidence]

Dose: 200 mg PO bid; Info: used w/ antibiotic tx

traveler's diarrhea prophylaxis

[Possibly Effective]

Dose: 250-1000 mg PO qd

ulcerative colitis

[Insufficient Evidence]

Dose: 250 mg PO tid

ventilator-assoc. pneumonia prevention

[Insufficient Evidence]

Dose: 1.5 billion CFUs PO bid