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S. boulardii
Saccharomyces boulardii
Entire Monograph
Reported Uses
- NOTE: see Herb & Supplement Effectiveness Rating Definitions table
- acne [Insufficient Evidence]
- candidiasis, vulvovaginal [Insufficient Evidence]
- C. difficile infection [Possibly Effective]
- cholera [Insufficient Evidence]
- cognitive function [Insufficient Evidence]
- constipation [Insufficient Evidence]
- critical illness (trauma) [Insufficient Evidence]
- Crohn dz [Insufficient Evidence]
- cystic fibrosis [Insufficient Evidence]
- diarrhea [Likely Effective]
- diarrhea, antibiotic-assoc. [Possibly Effective]
- diarrhea, HIV/AIDS-related [Insufficient Evidence]
- diarrhea, rotaviral [Possibly Effective]
- exercise-induced muscle soreness [Insufficient Evidence]
- heart failure [Insufficient Evidence]
- hypercholesterolemia [Insufficient Evidence]
- H. pylori infection [Possibly Effective]
- intestinal parasite infection [Insufficient Evidence]
- IBS [Insufficient Evidence]
- low birth weight [Insufficient Evidence]
- necrotizing enterocolitis [Possibly Effective]
- neonatal jaundice [Insufficient Evidence]
- obesity [Insufficient Evidence]
- periodontitis [Insufficient Evidence]
- postop infection [Insufficient Evidence]
- postop recovery [Insufficient Evidence]
- sepsis [Possibly Ineffective]
- small intestinal bacterial overgrowth (SIBO) [Insufficient Evidence]
- traveler's diarrhea prophylaxis [Possibly Effective]
- ulcerative colitis [Insufficient Evidence]
- UTI [Insufficient Evidence]
- ventilator-assoc. pneumonia [Insufficient Evidence]
Reported Doses
Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely
Special Note
- [formulation clarification]
- Info: uses and doses represent various probiotic-containing products; select proprietary products noted below
- [Florastor products]
- Info: each capsule or powder pkt contains 250 mg Saccharomyces boulardii lyo CNCM I-745
Effectiveness Ratings
- [see Herb & Supplement Effectiveness Rating Definitions table]
C. difficile infection
- [Possibly Effective]
- Dose: 500 mg PO bid; Alt: 10-30 billion CFUs PO qd; Info: used w/ antibiotic tx
constipation, peds pts
- [Insufficient Evidence]
- Dose: 500-750 mg PO qd; Info: for pts 6 mo-12 yo
critical illness (trauma)
- [Insufficient Evidence]
- Dose: 500 mg PO qid; Alt: 1.5 billion CFUs PO bid
Crohn dz
- [Insufficient Evidence]
- Dose: 250 mg PO tid; Alt: 1000 mg PO qd
diarrhea, adult pts
- [Likely Effective]
- Dose: 500 mg PO qid
diarrhea, peds pts
- [Likely Effective]
- Dose: 150-250 mg PO qd-bid; Alt: 5-10 billion CFUs PO qd; 1750 billion-175 trillion CFUs PO bid
diarrhea, antibiotic-assoc., adult pts
- [Possibly Effective]
- Dose: 250-500 mg PO bid-qid; Max: 1000 mg/day
diarrhea, antibiotic-assoc., peds pts
- [Possibly Effective]
- Dose: 250 mg PO qd-bid
diarrhea, HIV/AIDs-related
- [Insufficient Evidence]
- Dose: 3 g PO qd
diarrhea, rotaviral, peds pts
- [Possibly Effective]
- Dose: 200-250 mg PO bid
exercise-induced muscle soreness
- [Insufficient Evidence]
- Dose: 250 mg PO qd; Info: used w/ other probiotics
heart failure
- [Insufficient Evidence]
- Dose: 1000 mg PO qd
H. pylori infection
- [Possibly Effective]
- Dose: 100-1000 mg PO qd; Alt: 500 mg PO bid; Info: used w/ standard tx in adult and peds pts
intestinal parasite infection
- [Insufficient Evidence]
- Dose: 250 mg PO tid; Info: used w/ standard tx
IBS
- [Insufficient Evidence]
- Dose: 200 billion CFUs PO qd
low birth weight
- [Insufficient Evidence]
- Dose: 50 mg/kg/dose PO bid; Info: used in preterm infants
necrotizing enterocolitis
- [Possibly Effective]
- Dose: 100-200 mg/kg/dose PO qd; Info: used in preterm infants
neonatal jaundice
- [Insufficient Evidence]
- Dose: 250 mg PO qd
small intestinal bacterial overgrowth (SIBO)
- [Insufficient Evidence]
- Dose: 200 mg PO bid; Info: used w/ antibiotic tx
traveler's diarrhea prophylaxis
- [Possibly Effective]
- Dose: 250-1000 mg PO qd
ulcerative colitis
- [Insufficient Evidence]
- Dose: 250 mg PO tid
ventilator-assoc. pneumonia prevention
- [Insufficient Evidence]
- Dose: 1.5 billion CFUs PO bid
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