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flame grape
grape (Vitis spp.)
Reported Doses
Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely
Effectiveness Ratings
- [see Herb & Supplement Effectiveness Rating Definitions table]
Special Note
- [formulation clarification]
- Info: may incl. whole fruit, juice, pomace, or extracts of fruit, seed, leaf or vine; extracts generally stdzd to polyphenol or proanthocyanidin content
aging skin
- [Insufficient Evidence]
- Dose: 10 mg fruit extract PO bid
atherosclerosis
- [Insufficient Evidence]
- Dose: 120 mg seed extract PO qd; Info: extract containing >95% proanthocyanidins
athletic performance
- [Insufficient Evidence]
- Dose: 400 mg fruit extract PO qd
chronic venous insufficiency
- [Possibly Effective]
- Dose: 360-720 mg red vine leaf extract PO qd
cognitive function
- [Insufficient Evidence]
- Dose: 250 mg fruit extract PO qd; Alt: 355 mL fruit juice PO qd
diabetes mellitus
- [Insufficient Evidence]
- Dose: 200 mg fruit extract PO qd-bid; Info: given 40min before meal
diabetic retinopathy
- [Insufficient Evidence]
- Dose: 50 mg seed extract PO tid; Info: extract containing proanthocyanidins
erectile dysfxn
- [Insufficient Evidence]
- Dose: 200 mg fruit extract PO qd; Info: given 40min before meal
HTN
- [Insufficient Evidence]
- Dose: 150 mg seed extract PO bid
melasma
- [Insufficient Evidence]
- Dose: 54 mg seed extract PO tid; Info: extract containing 81% proanthocyanidins
menopausal sx
- [Insufficient Evidence]
- Dose: 200 mg seed extract PO qd; Info: extract containing 81% proanthocyanidins
metabolic syndrome
- [Insufficient Evidence]
- Dose: 150-300 mg seed extract PO qd; Alt: 8 g pomace PO qd; 46 g polyphenol powder PO qd; 18 mL/kg/dose juice PO qd
minor external bleeding
- [Insufficient Evidence]
- Dose: apply 1 mL/spray topically x4; Info: product containing 8 mg/100 mL grape leaf extract
nonalcoholic fatty liver dz
- [Insufficient Evidence]
- Dose: 1000 mg seed extract PO bid
wound healing
- [Insufficient Evidence]
- Dose: apply 2% cream topically bid; Alt: apply 5% ointment topically bid; Info: products prepared w/ grape seed extract
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