pineapple fruit bromelain

Reported Uses

• NOTE: see Herb & Supplement Effectiveness Rating Definitions table
• allergic rhinitis [Insufficient Evidence]
• arthralgia, aromatase inhibitor-induced [Insufficient Evidence]
• burn debridement [Insufficient Evidence]
• cancer [Insufficient Evidence]
• dental pain, postop [Insufficient Evidence]
• diabetes mellitus [Insufficient Evidence]
• diabetic foot ulcers [Insufficient Evidence]
• exercise-induced muscle soreness [Insufficient Evidence]
• exercise-induced respiratory infection [Insufficient Evidence]
• knee pain [Insufficient Evidence]
• lymphedema [Insufficient Evidence]
• multiple sclerosis [Insufficient Evidence]
• nephrolithiasis [Insufficient Evidence]
• ocular floaters [Insufficient Evidence]
• osteoarthritis [Insufficient Evidence]
• pain, acute [Insufficient Evidence]
• pain, postop [Insufficient Evidence]
• parturition [Insufficient Evidence]
• periodontitis [Insufficient Evidence]
• peripheral neuropathy, chemo-induced [Insufficient Evidence]
• pityriasis lichenoides chronica [Insufficient Evidence]
• rhinosinusitis [Insufficient Evidence]
• sprains [Insufficient Evidence]
• swelling, postop [Insufficient Evidence]
• tendinopathy [Insufficient Evidence]
• UTI [Insufficient Evidence]
• venous leg ulcers [Insufficient Evidence]
• wound healing [Insufficient Evidence]

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

arthralgia, aromatase inhibitor-induced

[Insufficient Evidence]

Dose: 20 mg PO qd

burn debridement

[Insufficient Evidence]

Dose: apply gel topically x1; Info: apply under occlusive dressing x4h

dental pain, postop

[Insufficient Evidence]

Dose: 160-1500 mg/day PO divided tid-qid x4-6 days; Alt: 200 mg PO x1 given 1h before surgery, then 200 mg PO q6h after surgery

exercise-induced muscle soreness

[Insufficient Evidence]

Dose: 50 mg PO qid

knee pain

[Insufficient Evidence]

Dose: 200-400 mg PO qd

lymphedema

[Insufficient Evidence]

Dose: 100 mg PO qd

nephrolithiasis

[Insufficient Evidence]

Dose: 500 mg PO qd; Info: used w/ tamsulosin

ocular floaters

[Insufficient Evidence]

Dose: 190 mg PO qd-tid

osteoarthritis

[Insufficient Evidence]

Dose: 180 mg PO tid; Alt: 300 mg PO bid-tid; 250 mg PO bid

pain, postop

[Insufficient Evidence]

Dose: 50 mg PO qd

periodontitis

[Insufficient Evidence]

Dose: 500 mg PO bid

peripheral neuropathy, chemo-induced

[Insufficient Evidence]

Dose: 20 mg PO qd

pityriasis lichenoides chronica

[Insufficient Evidence]

Dose: 40 mg PO tid x1mo, then 40 mg PO bid x1mo, then 40 mg PO qd x1mo

rhinosinusitis, adult pts

[Insufficient Evidence]

Dose: 40 mg PO qid x6 days; Alt: 200 mg PO qd-bid; Info: used w/ standard tx

rhinosinusitis, peds pts

[Insufficient Evidence]

Dose: 200 mg PO qd-bid; Info: for pts 12 yo and older; used w/ inhaled corticosteroids

swelling, postop

[Insufficient Evidence]

Dose: 180 mg PO bid; Info: used w/ standard tx

tendinopathy

[Insufficient Evidence]

Dose: 100 mg PO qd

wound healing

[Insufficient Evidence]

Dose: apply gel topically x4h up to 10x/day