poly E

Reported Uses

• NOTE: see Herb & Supplement Effectiveness Rating Definitions table
• acne [Insufficient Evidence]
• amyloidosis [Insufficient Evidence]
• anxiety [Insufficient Evidence]
• athletic performance [Insufficient Evidence]
• beta-thalassemia [Insufficient Evidence]
• cancer prevention, bladder [Insufficient Evidence]
• cancer prevention, breast [Insufficient Evidence]
• cancer prevention, colorectal [Insufficient Evidence]
• cancer prevention, endometrial [Possibly Effective]
• cancer prevention, esophageal [Insufficient Evidence]
• cancer prevention, gastric [Insufficient Evidence]
• cancer prevention, kidney [Insufficient Evidence]
• cancer prevention, liver [Insufficient Evidence]
• cancer prevention, lung [Insufficient Evidence]
• cancer prevention, nasopharyngeal [Insufficient Evidence]
• cancer prevention, oral [Insufficient Evidence]
• cancer prevention, ovarian [Possibly Effective]
• cancer prevention, pancreatic [Insufficient Evidence]
• cardiovascular dz prevention [Possibly Effective]
• cervical CA [Insufficient Evidence]
• cervical dysplasia [Insufficient Evidence]
• chronic fatigue syndrome [Insufficient Evidence]
• cognitive decline, age-related [Insufficient Evidence]
• cognitive function [Insufficient Evidence]
• cognitive impairment [Insufficient Evidence]
• colorectal adenoma [Insufficient Evidence]
• common cold [Insufficient Evidence]
• COPD [Insufficient Evidence]
• Crohn dz [Insufficient Evidence]
• dementia [Insufficient Evidence]
• dental plaque [Insufficient Evidence]
• depression [Insufficient Evidence]
• diabetes mellitus, type 2 [Insufficient Evidence]
• diabetic neuropathy [Insufficient Evidence]
• diarrhea, radiation-induced [Insufficient Evidence]
• Down syndrome [Insufficient Evidence]
• dry eye dz [Insufficient Evidence]
• dysmenorrhea [Insufficient Evidence]
• fracture [Insufficient Evidence]
• genital warts [Likely Effective]
• gingivitis [Insufficient Evidence]
• headache [Insufficient Evidence]
• HTN [Insufficient Evidence]
• hyperlipidemia [Possibly Effective]
• hypotension [Insufficient Evidence]
• infertility [Insufficient Evidence]
• influenza [Insufficient Evidence]
• Japanese cedar pollinosis [Insufficient Evidence]
• leukemia [Insufficient Evidence]
• mental alertness [Insufficient Evidence]
• metabolic syndrome [Insufficient Evidence]
• MI prevention [Insufficient Evidence]
• multiple myeloma [Insufficient Evidence]
• nausea/vomiting, radiation-induced [Insufficient Evidence]
• nephrolithiasis prevention [Insufficient Evidence]
• nonalcoholic fatty liver dz [Insufficient Evidence]
• non-Hodgkin lymphoma [Insufficient Evidence]
• obesity [Insufficient Evidence]
• oral leukoplakia [Insufficient Evidence]
• osteopenia [Insufficient Evidence]
• osteoporosis [Insufficient Evidence]
• overall mortality [Insufficient Evidence]
• pain, postop [Insufficient Evidence]
• Parkinson dz [Insufficient Evidence]
• periodontitis [Insufficient Evidence]
• pneumonia [Insufficient Evidence]
• polycystic ovary syndrome [Insufficient Evidence]
• prostate CA [Insufficient Evidence]
• radiation dermatitis [Insufficient Evidence]
• skin CA [Insufficient Evidence]
• SLE [Insufficient Evidence]
• stress [Insufficient Evidence]
• stroke prevention [Insufficient Evidence]
• sunburn [Insufficient Evidence]
• tinea pedis [Insufficient Evidence]
• ulcerative colitis [Insufficient Evidence]
• URI [Insufficient Evidence]
• UTI [Insufficient Evidence]
• wrinkled skin [Insufficient Evidence]

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Special Note

[formulation clarification]

Info: may incl. tea, beverages or extracts; green tea products contain polyphenols, such as catechin, incl. epigallocatechin-3-gallate (EGCG), and varying amounts of caffeine; see sinecatechins for FDA-approved Rx product; all other preparations are not FDA-approved

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

acne

[Insufficient Evidence]

Dose: apply 1-5% EGCG solution topically bid

amyloidosis

[Insufficient Evidence]

Dose: 500-700 mg EGCG PO qd; Info: used as tea or capsules

athletic performance

[Insufficient Evidence]

Dose: 945 mg/day EGCG PO divided tid; Alt: 640 mg polyphenols PO x1 given 90min before exercise

beta-thalassemia

[Insufficient Evidence]

Dose: 3 cups green tea PO qd; Info: used w/ standard tx

cancer prevention, breast

[Insufficient Evidence]

Dose: 3 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

cancer prevention, gastric

[Insufficient Evidence]

Dose: 10 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

cancer prevention, kidney

[Insufficient Evidence]

Dose: 5 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

cancer prevention, liver

[Insufficient Evidence]

Dose: 4 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

cancer prevention, lung

[Insufficient Evidence]

Dose: 7-10 cups green tea PO qd

cancer prevention, oral

[Insufficient Evidence]

Dose: 500-1000 mg/m^2/dose green tea extract PO tid

cancer prevention, ovarian

[Possibly Effective]

Dose: 2 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

cardiovascular dz prevention

[Possibly Effective]

Dose: 1-5 cups green tea PO qd; Alt: 300-1500 mL green tea PO qd

cervical dysplasia

[Insufficient Evidence]

Dose: 200 mg green tea extract PO qd

cognitive decline, age-related

[Insufficient Evidence]

Dose: 3 g green tea pwdr PO qd; Alt: 336.4 mg catechins PO qd

cognitive function

[Insufficient Evidence]

Dose: 170 mg catechins PO qd

cognitive impairment

[Insufficient Evidence]

Dose: 720 mg green tea extract PO bid; Alt: 2 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

colorectal adenoma

[Insufficient Evidence]

Dose: 1.5 g green tea extract PO qd; Alt: 150 mg EGCG PO bid

dementia

[Insufficient Evidence]

Dose: 1 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

dental plaque, peds pts

[Insufficient Evidence]

Dose: 2.5-5% mouthwash swish/spit bid; Info: for pts 10-14 yo; used w/ ginger extract

depression

[Insufficient Evidence]

Dose: 1 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

diabetes mellitus, type 2

[Insufficient Evidence]

Dose: 1 or more cups green tea PO qd-qwk; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

diabetic neuropathy

[Insufficient Evidence]

Dose: 500 mg decaffeinated green tea extract PO tid

diarrhea, radiation-induced

[Insufficient Evidence]

Dose: 450 mg PO qd

dry eye dz

[Insufficient Evidence]

Dose: apply green tea extract topically to eye(s) tid

gingivitis, peds pts

[Insufficient Evidence]

Dose: 2.5-5% mouthwash swish/spit bid; Info: for pts 10-14 yo; used w/ ginger extract

HTN

[Insufficient Evidence]

Dose: 3 g/150 mL green tea PO tid; Alt: 379-1500 mg green tea extract PO qd

hyperlipidemia

[Possibly Effective]

Dose: 150-2500 mg catechins/day PO divided qd-tid

hypotension

[Insufficient Evidence]

Dose: 400 mL green tea PO qd

influenza

[Insufficient Evidence]

Dose: 270 mg EGCG PO qd; Alt: 5 or more cups green tea PO qwk

Japanese cedar pollinosis

[Insufficient Evidence]

Dose: 350 mL green tea PO bid; Info: tea stdzd to contain 5.83-6.72 mg O-methylated catechin/100 mL

MI prevention

[Insufficient Evidence]

Dose: 3 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

nonalcoholic fatty liver dz

[Insufficient Evidence]

Dose: 700 mL green tea (1080 mg catechins) PO qd; Alt: 500-1000 mg green tea extract PO qd; 600 mg catechins PO qd

obesity, adult pts

[Insufficient Evidence]

Dose: 440-460 mg EGCG PO qd; Alt: 234-886 mg catechins/day PO divided qd-bid; 530 mg decaffeinated green tea extract PO bid; 270 mg EGCG/day PO divided bid; 500 mg green tea PO qd; 300 mg green tea extract PO bid; 10 g powdered green tea PO bid; 3-4 cups green tea PO qd

obesity, peds pts

[Insufficient Evidence]

Dose: 576 mg catechins PO qd; Alt: 400 mg decaffeinated green tea polyphenols PO qd

oral leukoplakia

[Insufficient Evidence]

Dose: 3 g green tea/day PO divided qid plus 10% solution topically tid

osteopenia

[Insufficient Evidence]

Dose: 1-3 cups green tea PO qd; Alt: 500 mg polyphenols PO bid

osteoporosis

[Insufficient Evidence]

Dose: 1-3 cups green tea PO qd

overall mortality

[Insufficient Evidence]

Dose: 5 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

Parkinson dz

[Insufficient Evidence]

Dose: 1 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

pain, postop

[Insufficient Evidence]

Dose: 15 mL swish/spit bid; Info: 5% green tea extract solution

periodontitis

[Insufficient Evidence]

Dose: 1.55% green tea extract candies PO qd; Alt: apply 1% green tea extract gel topically to periodontal pocket x1

polycystic ovary syndrome

[Insufficient Evidence]

Dose: 1000-2000 mg green tea PO qd; Alt: 1620 mg EGCG PO qd

prostate CA

[Insufficient Evidence]

Dose: 200 mg catechins PO tid; Alt: 400 mg EGCG PO qd; 7 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

radiation dermatitis

[Insufficient Evidence]

Dose: 0.05 mL/cm^2 (660 mcmol/L EGCG) spray over radiation field tid; Start: 1st day of XRT

SLE

[Insufficient Evidence]

Dose: 500 mg green tea extract PO bid

stress

[Insufficient Evidence]

Dose: 300 mg green tea extract PO qd

stroke prevention

[Insufficient Evidence]

Dose: 1 or more cups green tea PO qd; Info: >12 cups/day assoc. w/ significant adverse effects, incl. tachyarrhythmia, sleep disturbance

sunburn

[Insufficient Evidence]

Dose: 540-1402 mg catechins PO qd

tinea pedis

[Insufficient Evidence]

Dose: 0.1% green tea solution footbath x15min qd

ulcerative colitis

[Insufficient Evidence]

Dose: 200-400 mg green tea extract PO bid

UTI

[Insufficient Evidence]

Dose: 2000 mg green tea extract PO qd; Info: used w/ sulfamethoxazole/trimethoprim

wrinkled skin

[Insufficient Evidence]

Dose: 1 L green tea beverage PO qd; Alt: 300 mg green tea extract PO bid plus 10% green tea cream topically qd