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FDA

FDA expands Casgevy label to younger children with sickle cell disease

First gene therapy approved for children as young as 2 years with sickle cell disease and transfusion-dependent β-thalassemia. . .

PLoS Med

Swapping light activity for sitting tied to lower cancer mortality

Prolonged unbroken sedentary time was tied to higher cancer mortality, while interrupted sitting tracked the other way. . .

Infect Immun

Could lipid antibodies unlock earlier Lyme diagnosis?

New data suggest antiphospholipid antibodies may identify Lyme disease before standard serologic tests turn positive and help distinguish patients with persistent post-treatment symptoms. . .

JAMA Netw Open

SGLT2 inhibitors tied to lower dementia risk in psychiatric patients

VA data suggest a possible neuroprotective role in older adults with mood and psychotic disorders. . .

Obstet Gynecol

Self-collected HPV testing enters mainstream in updated cervical screening guidance

Primary hrHPV testing every 5 years is now the preferred strategy, with self-collection expanding access. . .

J Am Heart Assoc

GLP-1 drugs may protect limbs in diabetes with PAD

Strongest associations were seen in patients with diabetes plus severe peripheral artery disease or obesity. . .

JAMA Netw Open

Long-acting PrEP uptake is rising—but persistence lags

Injectable cabotegravir made up only a small share of US PrEP use, and fewer than 1 in 4 users stayed on it for 2 years. . .

npj Vaccines

COVID boosters may broaden immunity against animal coronaviruses

Broader antibody responses could matter if SARS-CoV-2–related animal viruses emerge in humans. . .

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