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A pragmatic trial of genotype-guided SSRI prescribing found no benefit at three months but higher remission rates at six months, suggesting the value of pharmacogenetic testing emerges over time rather than immediately. . .

A study of 33 wealthy countries from 1990 to 2022 found that fewer hours worked track with lower adult obesity, with men showing the strongest effect. . .

Patients achieving ≥15% weight loss by 24 weeks on semaglutide 7.2 mg averaged 27.7% weight reduction at 72 weeks, with most weight loss driven by fat mass reduction. . .

A new, mRNA-based influenza vaccine reduced flu by 27% compared with standard-dose vaccines in adults 50 and older, but with notably higher rates of fatigue, headache, myalgia, and injection-site pain. . .

A global consensus retired polycystic ovary syndrome in favor of polyendocrine metabolic ovarian syndrome, a name built around the endocrine and cardiometabolic features at the core of the disease. . .

A new committee statement sets consistent ethical standards for how ob-gyns should counsel patients on pregnancy options, with patient autonomy at the center regardless of practice setting, personal beliefs, or local legal restrictions. . .

Ultra-processed food intake should be treated as a distinct cardiovascular risk factor, not just a marker of poor nutrient content, according to a new European cardiology consensus statement. . .

In selected ischemic stroke patients with poor early response to tenecteplase, tirofiban improved 90-day functional outcomes. . .

CDC launched a 42-day quarantine operation for US passengers from the MV Hondius, an expedition cruise ship returning from Antarctica, after at least eight people aboard tested positive for Andes hantavirus and three died. . .