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JAMA Pediatr

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Nirsevimab RSV protection fades by second year

Longer-term data show a single dose does not protect against RSV hospitalization the following season or reduce later asthma risk. . .

JAMA Netw Open

Does childhood maltreatment accelerate biological aging?

Adults with documented childhood maltreatment showed small differences in biological aging, which became even smaller after accounting for smoking and BMI.

Nat Microbiol

Early triple therapy may offer path toward curing newborn HIV

Preclinical study found no detectable virus after treatment ended, raising hopes that lifelong therapy could be avoided. . .

JAMA

ctDNA spots cancer relapse months early

Detectable tumor DNA reliably flags recurrence ahead of imaging, and trials have shown it can guide treatment decisions after surgery. . .

FDA

FDA approves Tudriqev, engineered viral therapy for PD-1–resistant melanoma

New intratumoral immunotherapy combines direct tumor killing with immune activation for patients whose melanoma has progressed despite PD-1 blockade. . .

JAMA Pediatr

Flu antiviral use is falling--in children guidelines target

The retreat from treatment arrived without new evidence behind it, and an eight-season surveillance analysis makes the case for treating harder to set aside. . .

JAMA Neurol

Blood tests move from amyloid detection to tau staging

Pairing an existing protein biomarker with additional blood proteins gave a more reliable read on advanced tau buildup. It left fewer patients with unclear results that would otherwise send them for a PET scan. . .

JAMA Netw Open

BMI, waist measures best recent obesity criteria

These offered a better balance for routine clinical use, as compared to a recent Lancet definition. . .

JAMA

JAMA offers a patient script for the cannabis talk

Few patients volunteer that they are using, and the resource gives clinicians a way to open the conversation and structure what follows. . .