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In a network meta-analysis of antipsychotic-treated patients, semaglutide produced the largest weight reduction ahead of liraglutide, topiramate, metformin, and exenatide. . .

New consensus statement urges clinicians to pair incretin-based obesity therapies with tailored nutrition, function, and mental health support. . .

PACIFIC trial analysis suggests baseline proton pump inhibitor use was associated with shorter progression-free and overall survival during consolidation immunotherapy. . .

Small N-of-1 trial found wide variation in symptom benefit, with about 1 in 3 men seeing little or no effect. . .

Large SEER-Medicare analysis found no evidence that vaginal estrogen worsened overall or breast cancer–specific survival in older women with breast cancer. . .

The largest genetic study of IBS links the condition to triglyceride metabolism, suggesting a cardiometabolic dimension beyond its established gut-brain roots. . .