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Most of what patients shed is fat and relative muscle mass holds up, but proportionally more lean tissue is lost than with diet and exercise interventions. . .

A meta-analysis of 37 studies covering more than 600,000 antidepressant-exposed pregnancies found that small associations with autism and ADHD disappeared once researchers accounted for parental mental health and shared family factors. . .

Young adults with childhood-onset severe obesity that had resisted years of structured pediatric care saw meaningful BMI reductions and broad metabolic gains on weekly semaglutide, with treatment effect independent of prior response. . .

Heart attack survivors showed faster decline on memory and thinking tests than people without a history of myocardial infarction. . .

Young adults starting dialysis were more likely to receive predialysis nephrology care, longer dialysis sessions, and peritoneal dialysis after Affordable Care Act Medicaid expansion. . .

Vyvgart and Vyvgart Hytrulo are now approved for all adult gMG serotypes, including MuSK-positive, LRP4-positive, and triple seronegative disease. . .

A network meta-analysis found meaningful differences in efficacy, acceptability, and tolerability among FDA-approved atypical antipsychotics used adjunctively for major depressive disorder. . .

Adults with asthma who started a GLP-1 receptor agonist had 26% fewer exacerbations and 14% lower reliever inhaler use in the year after starting treatment, in a nationwide Danish cohort. . .

Obesity experts, dietitians, and patient advocacy groups issue joint guidance calling for dietitian-led nutrition therapy, body composition monitoring, and psychological screening for patients on incretin-based weight-loss drugs. . .