By vgreene, 2 September, 2020 Meta-analysis of Effect of Statins in Patients With COVID-19; access full-text Am J Cardiol article
By vgreene, 2 September, 2020 Effect of Hydroxychloroquine With or Without Azithromycin on the Mortality of COVID 19 Patients A Systematic Review and Meta analysis
By vgreene, 2 September, 2020 Study considerations: varying dz severity; HCQ admin (dosing, timing, duration) highly heterogeneous; aggregate analysis not w/ original pt data; mostly incl observational studies
By vgreene, 2 September, 2020 HCQ not significantly assoc w/ mortality (pooled RR 0.83, 95% CI 0.65-1.06 for all studies, I2=84%; pooled RR 1.09, 95% CI 0.97-1.24 for RCTs, I2=0%); HCQ+AZ assoc w/ incr mortality (RR 1.27, 95% CI 1.04-1.54, I2=38%)
By vgreene, 2 September, 2020 Meta-analysis incl 3 RCTs, 1 interventional non-randomized study (w/ critical bias risk), 25 observational studies (15 studies w/ mod or serious bias risk, 10 w/ critical bias risk); study quality lowered by lack of info for tx assignment, time to interve
