By vgreene, 29 May, 2020 Drugs under investigation: dexamethasone, methylprednisolone, inhaled budesonide, inhaled ciclesonide
By vgreene, 29 May, 2020 Pharmacokinetic studies show that higher doses (at least 3x usual dose) may be needed to achieve adequate concentrations for antiviral activity
By vgreene, 29 May, 2020 Study considerations: no placebo control; randomization not stratified; protocol amended mid-study to lower age eligibility limit; 10-day group sicker at baseline; not all pts completed full course of assigned RDV; viral load not evaluated; extension phas
By vgreene, 29 May, 2020 Unadjusted analysis of 14-day clinical status improvement rate: 5-day 64%, 10-day 54%, w/ no difference after adjusted analysis; ADRs incl acute resp failure (5-day 5%, 10-day 9%), resp failure (5-day 2%, 10-day 5%), grade 4 CrCl reduction (5-day 3%, 10-d