By vgreene, 29 May, 2020 Randomized, multicenter, multinational, open-label study: 397 hospitalized pts w/ confirmed SARS-CoV-2, pneumonia, and O2 sat ≤94% on RA or receiving supplemental O2, randomized 1:1 to receive RDV 200 mg IV x1, then 100 mg IV q24h x5 days total (n=200, me
By vgreene, 29 May, 2020 GI adverse effects reported w/ doses >6 g/day, incl nausea, stomachache, diarrhea10
By vgreene, 29 May, 2020 HSV. Oral L-lysine 3 g/day appear to improve subjective pt experience, per review; more studies needed to definitively test role in herpes simplex prophylaxis & determine minimum reliably effective dose.8 Topical L-lysine w/ zinc & herbals as ointment for
By vgreene, 29 May, 2020 Viral replication hypothesis: Studied in HSV infxn5 (primarily cold sores), possible mechanism involves blocking arginine needed for HSV-1 replication;6 raised as theoretical means of blocking viral RNA replication, as tx for COVID-197
By vgreene, 29 May, 2020 Antiviral/immune system hypothesis: Has been proposed for COVID-19 tx/prevention based on immune-boosting & antiviral potential (eg, in HSV)2-4