By vgreene, 11 May, 2020 Potential drug interactions: may inhibit CYP2D6 substrates, CYP3A4 substrates17
By vgreene, 11 May, 2020 Allergic contact dermatitis w/ topical use;16 nausea, bloating, burning sensation w/ oil form, slight ↑liver/kidney enzymatic markers reported w/ oil & crushed seeds14
By vgreene, 11 May, 2020 Asthma. Evidence mixed,14 1 meta-analysis finds potential benefits in ↑asthma control scores & FEV1, but no clear effect on PEF15
By vgreene, 11 May, 2020 HCV. Limited evidence, eg, ↓viral load w/ Nigella sativa seed oil 450 mg PO tid (N=30, no control) & w/ Nigella sativa 500 mg PO bid vs control (N=60)12,13
By vgreene, 11 May, 2020 Acute tonsillopharyngitis. Nigella sativa capsules 360 mg + Phyllanthus niruri 50 mg extracts PO tid x7 days vs placebo improved sore throat pain, swallowing difficulty (RCT, N=186)11
By vgreene, 11 May, 2020 COVID-19 tx trial. Nigella sativa seed powder 2 g + honey 30 mL PO bid in COVID-19 pts, placebo-controlled RCT in Pakistan10