By vgreene, 28 April, 2020 High priority: inpt; symptomatic healthcare worker/1st responder/congregate living setting worker; symptomatic pt in long-term care facility (incl prison, shelter); public health cluster/contact investigations
By vgreene, 28 April, 2020 Recent exposure to known/suspected case; testing recommended for all neonates born to mother w/ suspected/ confirmed COVID-19 regardless of absence of signs/sx in mother & neonate
By vgreene, 28 April, 2020 periodic testing (incl asymptomatic pts) for early detection in close-quarter, vulnerable settings (eg, nursing homes)
By vgreene, 27 April, 2020 Proposed mechanism: reduces inflammatory response by inhibiting IL-1 receptors
By vgreene, 27 April, 2020 Proposed mechanism: inhibits fusion of viral and cellular membranes by intercalating into membrane lipids
By vgreene, 27 April, 2020 Open-label, non-randomized, before-after controlled study; 80 pts (median age, 47y) w/ confirmed COVID-19 received either FPV 1,600 mg bid x2 doses, then 600 mg bid (n=35) or LPV/r 400 mg/100 mg bid (n=45) for up to 14 days or until viral clearance; pts e
By vgreene, 27 April, 2020 Proposed mechanism: terminates viral replication by binding to RNA-dependent RNA polymerase