By vgreene, 27 April, 2020 Chronic rhinosinusitis sx. Low evidence quality didn’t permit conclusions in a meta-analysis10
By vgreene, 27 April, 2020 URI sx. Unblinded RCT on hypertonic saline nasal irrigation & gargling w/in 48h of URI onset (N=61, mostly rhinoviruses, coronaviruses) showed ↓illness duration by 1.9 days, 36% ↓OTC remedy use, 35% ↓household transmission, ↓viral shed
By vgreene, 27 April, 2020 Other influencers recommend against nasal irrigation during COVID-19, d/t concern that nasal rinse devices could harbor infectious droplets6 or use could ↑risk of aerosolizing infectious droplets7
By vgreene, 27 April, 2020 Proposed to reduce COVID-19 sx progression based on historical use as remedy to ↓cold/flu sx3-5—though not studied in SARS-CoV-2
By vgreene, 27 April, 2020 Proposed to reduce COVID-19 sx progression based on historical use as remedy to ↓cold/flu sx3-5—though not studied in SARS-CoV-2
By vgreene, 27 April, 2020 There s no scientific evidence that saline nasal irrigation or any alternative remedy is effective for COVID 19 prevention tx1 2
By vgreene, 27 April, 2020 NINDS inclusion/exclusion criteria for IV tPA (alteplase) in ischemic stroke [nid:217336]