By vgreene, 16 April, 2020 Study considerations: non-comparative; small sample size; excl pts w/ severe organ dysfxn; pts received other antiviral agents; delayed tx initiation from hospital admission
By vgreene, 16 April, 2020 Sx and oxygenation improved in all pts; 2 pts extubated, 1 pt D/C high-flow NC; all pts had negative viral load by day 6 post-transfusion (3 pts w/ negative viral load before transfusion); no serious safety events reported
By vgreene, 16 April, 2020 Donors recovered from COVID-19, afebrile for >3 days, negative viral load on consecutive samples; donor transfusions had neutralizing Ab titers >1:640
By vgreene, 16 April, 2020 Case series; 10 pts (median age, 53y) w/ severe COVID-19; all pts received other antivirals, 6 pts received methylprednisolone; 3 pts mechanically ventilated, 3 pts on high-flow NC, 4 pts on low-flow NC or RA; all pts received 200 mL convalescent plasma x
By vgreene, 16 April, 2020 Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma