By vgreene, 16 April, 2020 Study considerations: non-comparative; small sample size; pts received other antivirals; delayed tx initiation from hospital admission; safety data not reported
By vgreene, 16 April, 2020 SOFA scores, PaO2/FiO2 ratios, and fever curves improved for all pts w/ negative viral load by day 12 post-transfusion; 3 of 5 pts extubated and discharged home, remaining 2 pts still on mechanical ventilation
By vgreene, 16 April, 2020 Donors recovered from COVID-19, asymptomatic for >10 days, SARS-CoV-2-specific Ab titers >1:1000, neutralizing Ab titer >40
By vgreene, 16 April, 2020 Case series; 5 critically ill pts (ages 36-73y) w/ severe COVID-19 pneumonia and high viral load despite antiviral tx, PaO2/FiO2
By vgreene, 16 April, 2020 Proposed mechanism: impairs replication of various viruses, incl coronaviruses, by inhibiting RNA-dependent RNA polymerase; intracellular concentrations increased by HCQ and CQ