By vgreene, 7 April, 2020 A Prospective Clinical Study of Hydroxychloroquine in the Prevention of SARS-CoV-2 (COVID-19) Infection in Healthcare Workers After High-risk Exposures, NCT04333225
By vgreene, 7 April, 2020 See ascorbic acid vitamin C adverse events and drug interaction check in epocrates
By vgreene, 7 April, 2020 Generally safe diarrhea nausea abdominal cramps reported at high doses 9 oral doses equivalent to clinical trial IV doses could lead to serious GI adverse effects10
By vgreene, 7 April, 2020 Acute lower resp tract infxn tx. 200 mg PO qd in older inpts w/ bronchitis or pneumonia RCT (N=57; ages 66-94 yo; some vit C deficient): severity scores @ 4wk marginally significantly improved vs placebo--but only in most severely ill inpts, a group w/ lo
By vgreene, 7 April, 2020 Pneumonia prevention. 2 g PO qd in 8-wk RCT (N=674 US marine recruits) assoc w/ ↓pneumonia incidence vs placebo (OR, 0.23)3
By vgreene, 7 April, 2020 Cold duration severity Regular use of 200 mg PO qd assoc w 8 darr cold duration in adults 14 darr in children 31 trials N 9 745 episodes 1 2 g day darr duration by 18 in children per meta analysis 8 Cold severity 16 trials N 7 209 also darr eg by 5 in 1 R