By vgreene, 2 April, 2020 Hydroxychloroquine vs Azithromycin for Hospitalized Patients With Suspected of Confirmed COVID-10 (HAHPS); NCT04329832
By vgreene, 2 April, 2020 Published: Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Results of an Open-label Non-randomized Clinical Trial
By vgreene, 2 April, 2020 Treated pts had significant reduction in viral carriage at day 6 and much lower carriage duration vs controls; addition of azithromycin resulted in significantly more efficient virus elimination
By vgreene, 2 April, 2020 Single-arm protocol; 26 hospitalized pts (6 asymptomatic; 22 w/ URTI sx; 8 w/ LRTI sx) treated w/ HCQ 200 mg tid x10 days; 6 pts also received azithromycin (500 mg x1dose, then 250 mg daily x4 days) to prevent bacterial superinfxn: ECG was monitored daily
By vgreene, 2 April, 2020 Proposed mechanism: no direct antiviral activity; indirect immunomodulatory effects