By vgreene, 27 March, 2020 Active: Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19 (NOSARSCOVID)
By vgreene, 27 March, 2020 Adults w/ COVID-19 admitted to ICU, intubated and mechanically ventilated to be given inhaled NO until PaO2/FiO2 ≥300 mmHg
By vgreene, 27 March, 2020 Nitric Oxide Gas Inhalation Therapy in Spontaneous Breathing Patients With Mild/Moderate COVID-19: A Randomized Clinical Trial, NCT04305457
By vgreene, 27 March, 2020 Adults w/ lab-confirmed COVID-19 hospitalized w/ fever, resp rate ≥24, cough, spontaneous breathing w/ or w/o hypoxia
By vgreene, 27 March, 2020 Proposed mechanism: selectively dilates pulmonary vasculature, leading to vasodilation and increased oxygenation; reports of antiviral activity against other coronaviruses (eg, SARS-CoV)