By vgreene, 18 February, 2020 SU (later gen to lower hypoglycemia risk; glimepiride has shown similar safety to DPP4-I)
By vgreene, 18 February, 2020 If CKD w o albuminuria use either GLP1 RA w proven CVD benefit or or SGLT2 I w proven CVD benefit1 2
By vgreene, 18 February, 2020 For pts w albuminuria UACR 300 mg g and eGFR 25 Preferably use SGLT2 I w evidence of reducing CKD progression in either primary CKD or CV outcomes trials if SGLT2 I contraindicated ie eGFR
By vgreene, 18 February, 2020 Avoid TZD in setting of HF also potential uarr risk of worsening HF w saxagliptin
By vgreene, 18 February, 2020 Can continue metformin in stable HF as long as eGFR 30 but avoid if unstable or hospitalized HF B