By vgreene, 14 October, 2016
(BMJ)—A 28-yo pregnant woman (G1P0; 31wk gestation) presented to the ED w/ RUQ pain. Regular prenatal visits were normal. BP: 136/104 mm Hg. UA: (-)protein. WBC=14x109/L, plt=25x109/L, Hgb=9.4 g/dL. AST=304 U/L, ALT=356 U/L, bili normal. Blood film: schistocytes, thrombocytopenia. What is the dx?
Gestational thrombocytopenia
Acute fatty liver of pregnancy
Atypical hemolytic uremic syndrome
Immune thrombocytopenia purpura
HELLP syndrome
You are correct. HELLP ([H]emolysis, [E]levated [L]iver enzymes, and [L]ow [P]latelet count) syndrome typically develops in the 3rd trimester and is assoc w/ preeclampsia. Gestational thrombocytopenia is the most common cause of low platelets during pregnancy and resolves after delivery. Immune thrombocytopenia purpura (ITP) is typically assoc w/ bleeding manifestations in pts w/ a prior hx of ITP. Atypical hemolytic uremic syndrome is caused by complement dysregulation and rarely occurs during pregnancy. Acute fatty liver of pregnancy (AFLP) is differentiated from HELLP by the presence of severe hypoglycemia and coagulopathy. This pt was started on antihypertensives and MgSO4 and emergency C-section was performed. After delivery, BP normalized w/in 6h and platelet count recovered after 3 days; LDH and LFTs did not return to normal until 12 days later.
(BMJ)—A 44-yo man w/ untreated HIV infxn and CD4 count <50 cells/mm3 was referred by his PCP for routine screening. He had no eye complaints. Exam: VA 20/20 bilat. OD: white annular edge of hemorrhagic retinitis in brushfire pattern. OS: WNL. What is the dx?
Progressive outer retinal necrosis
Cotton wool spots
Herpes simplex virus infection
Toxoplasmosis
Cytomegalovirus infection
You are correct. CMV retinitis is the most common opportunistic ocular infxn in HIV/AIDS and is often described as “pizza pie,” “cheese and ketchup,” or “brushfire” retinitis. Dx was confirmed by PCR of biopsied intraocular fluid. Toxoplasmosis can present similarly, but the accompanying retinal hemorrhage is usually less severe. Progressive outer retinal necrosis (PORN), which is assoc w/ VZV infxn, manifests w/ yellow-white infiltrates and affects the macula early in its course vs CMV retinitis, which shows macular involvement later. This pt’s retinitis resolved to an inactive retinal scar after tx w/ HAART and PO valganciclovir.
(BMJ)—A 7-day-old girl, born at term and otherwise healthy, was referred w/ multiple skin lesions on her R arm. Exam: multiple vascular, slightly reticulate patches w/ deep purple rim and blue-to-gray atrophic center on R forearm. What is the dx?
Cutis marmorata telangiectatica congenita
Neonatal lupus erythematosus
Transient physiological cutis marmorata
Nevus anemicus
Reticular capillary malformation (port wine stain)
You are correct. Cutis marmorata telangiectatica congenita (CMTC) is a rare congenital cutaneous vascular malformation. CMTC is characterized by persistent reticulate erythema, telangiectasias, and skin atrophy or ulceration. It is distinguished from transient physiological cutis marmorata, which is susceptible to temp variation. The dx is clinical. CMTC tends to be self-limiting w/o tx. In this case, the reticulated erythema was significantly reduced at 6-mo f/u.