By vgreene, 28 October, 2021 Mean QTc interval increased from 435 msec at baseline to 463 msec 30 pts had QTc prolonged by 40 msec 11 pts developed QTc interval of 500 msec no cases of torsade de pointes acute renal failure only predictor of maximal QTc 500 msec on multivariate analy
By vgreene, 28 October, 2021 Retrospective observational study 84 hospitalized pts mean age 63y w confirmed SARS CoV 2 treated w HCQ plus AZ comorbidities incl CAD 11 HTN 65 CKD 7 DM 20 COPD 8 CHF 2 7 on amiodarone tx
By vgreene, 28 October, 2021 Study considerations non comparative small sample size pts had other risk factors for QT prolongation besides HCQ plus AZ tx HCQ and AZ dosing not provided
By vgreene, 28 October, 2021 The QT Interval in Patients With COVID 19 Treated With Hydroxychloroquine and Azithromycin
By vgreene, 28 October, 2021 FDA MedWatch Hydroxychloroquine or Chloroquine for COVID 19 Drug Safety Communication FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems see FDA alert
By vgreene, 28 October, 2021 Proposed mechanism inhibits viral entry and replication via intracellular alkalinization interferes w maturation of viral particles through impaired glycosylation indirect immunomodulatory effects
