By vgreene, 28 October, 2021 Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID 19 The TOGETHER Randomized Clinical Trial access JAMA Network Open article
By vgreene, 28 October, 2021 No significant difference in mean viral load reduction at day 3 or day 7 b w groups no significant reduction in hospitalization or time to sx resolution b w groups no pts required mech vent or died during study period no relevant tx assoc ADRs reported
By vgreene, 28 October, 2021 Multicenter open label RCT 293 non hospitalized pts mean age 41 6y w confirmed SARS CoV 2 infxn mild dz and
By vgreene, 28 October, 2021 Study considerations randomized but open label and not placebo controlled study protocol amended to remove DRV c tx option and to incl additional specimen collection at day 7 most pts were HCWs self reported compliance
