By vgreene, 28 October, 2021 Effect of Hydroxychloroquine in Hospitalized Patients With Covid 19 RECOVERY
By vgreene, 28 October, 2021 HCQ not significantly assoc w mortality pooled RR 0 83 95 CI 0 65 1 06 for all studies I2 84 pooled RR 1 09 95 CI 0 97 1 24 for RCTs I2 0 HCQ AZ assoc w incr mortality RR 1 27 95 CI 1 04 1 54 I2 38
By vgreene, 28 October, 2021 Meta analysis incl 3 RCTs 1 interventional non randomized study w critical bias risk 25 observational studies 15 studies w mod or serious bias risk 10 w critical bias risk study quality lowered by lack of info for tx assignment time to intervention unbala
By vgreene, 28 October, 2021 Study considerations varying dz severity HCQ admin dosing timing duration highly heterogeneous aggregate analysis not w original pt data mostly incl observational studies
By vgreene, 28 October, 2021 KEY FINDINGS HCQ alone not assoc w reduced mortality in hospitalized pts but HCQ AZ significantly increased mortality
By vgreene, 28 October, 2021 Effect of Hydroxychloroquine With or Without Azithromycin on the Mortality of COVID 19 Patients A Systematic Review and Meta analysis
