JAMA Netw Open
Incident stroke linked to rapid cognitive decline in older adults
October 15, 2024
Incident stroke was associated with both immediate and progressively worsening cognitive decline in older stroke survivors, according to findings from this cohort study utilizing pooled data from 14 cohorts.
The study involved 20,860 participants (average age, 72.9 years; 58.8% female) with a follow-up period of 7.51 years. Incident stroke led to a significant acute decline in global cognition (-0.25 standard deviation [SD]; 95% CI, -0.33 to -0.17), the Mini-Mental State Examination, and all cognitive domains (-0.17 to -0.22 SD). It also resulted in an accelerated decline in global cognition (-0.038 SD per year; 95% CI, -0.057 to -0.019 SD per year) and all domains except memory (-0.020 to -0.055 SD per year), compared with a stroke-free trajectory. There was no significant difference in prestroke cognitive decline between stroke survivors and individuals without stroke. Mean cognitive decline rate without stroke was -0.049 SD per year (95% CI, -0.051 to -0.047 SD).
Source:
Lo JW, et al. (2024, October 1). JAMA Netw Open. Trajectory of Cognitive Decline Before and After Stroke in 14 Population Cohorts. https://pubmed.ncbi.nlm.nih.gov/39356504/
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