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Hemiclor
chlorthalidone
Adult Dosing .
Dosage forms: TAB: 12.5 mg
Special Note
- [formulation clarification]
- Info: not interchangeable w/ Thalitone; do not substitute on a mg to mg basis
HTN
- [12.5-25 mg PO qam]
- Info: give w/ food
renal dosing
- [see below]
- renal impairment: not defined, caution advised; anuria: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment/progressive hepatic dz: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- anuria
- avoid: sun exposure
- avoid: UV light exposure, artificial
- caution: hypersensitivity to sulfonamides
- caution: renal impairment
- caution: hepatic impairment
- caution: hepatic dz, progressive
- caution: electrolyte abnormalities
- caution: volume depletion
- caution: seizure disorder
- caution: arrhythmia
- caution: post-sympathectomy
- caution: diabetes mellitus
- caution: SLE
- caution: gout hx
- caution: pancreatitis hx
- caution: HTN, gestational
- caution: elderly pts
Drug Interactions .
Overview
chlorthalidone
thiazide diuretic
- antihypertensive agent
- binds to anion exchange resin/polymer
- decreases renal perfusion/fxn
- diuretic
- hypercalcemia
- hyperglycemic effects
- hyperuricemic effects
- hypokalemia
- hypomagnesemia
- hyponatremia
- photosensitivity
- urine alkalinizer
Contraindicated
- isocarboxazid
- methenamine
Avoid/Use Alternative
- aldesleukin
- amikacin
- aminolevulinic acid topical
- aripiprazole lauroxil
- arsenic trioxide
- chlorothiazide
- clofarabine
- hydrochlorothiazide
- indapamide
- lofexidine
- mannitol
- metolazone
- porfimer
- sulfamethoxazole
Monitor/Modify Tx
- abaloparatide
- abiraterone acetate
- acarbose
- acetazolamide
- acyclovir
- adefovir dipivoxil
- albuterol
- albuterol inhaled
- alfentanil
- alfuzosin
- aliskiren
- allopurinol
- almotriptan
- aloe
- alogliptin
- amantadine
- amifostine
- amikacin inhaled
- amiloride
- amitriptyline
- amoxapine
- amphetamine
- amphotericin
- anthrax immune globulin
- apomorphine
- apraclonidine ophthalmic
- arformoterol inhaled
- aripiprazole bimonthly injection
- aripiprazole monthly injection
- aripiprazole oral
- armodafinil
- articaine
- asciminib
- asenapine
- asparaginase
- aspirin
- atomoxetine
- atropine ophthalmic
- auranofin
- avanafil
- axitinib
- azilsartan medoxomil
- balsalazide
- benazepril
- benzphetamine
- berberine
- betamethasone
- betaxolol ophthalmic
- bethanechol
- bevacizumab
- bexagliflozin
- bismuth subsalicylate
- bortezomib
- botulism immune globulin
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- bromocriptine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposomal
- buprenorphine
- bupropion
- butalbital
- butorphanol
- cabergoline
- cabozantinib
- caffeine
- caffeine citrate
- calcipotriene topical
- calcitriol
- calcitriol topical
- calcium acetate
- calcium carbonate
- calcium chloride
- calcium citrate
- calcium gluconate
- canagliflozin
- candesartan cilexetil
- cannabis
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- captopril
- carbamazepine
- carboplatin
- carfilzomib
- cariprazine
- carteolol ophthalmic
- celecoxib
- cetuximab
- chloroprocaine
- chlorpromazine
- cholecalciferol (vitamin D3)
- cholestyramine
- cidofovir
- cilostazol
- cisplatin
- citalopram
- clindamycin
- clomipramine
- clonidine
- clozapine
- cocaine
- codeine
- coenzyme Q-10
- colesevelam
- colestipol
- colistimethate
- copanlisib
- corticotropin
- cortisone
- creatine
- crizotinib
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- danazol
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- darbepoetin alfa
- decitabine
- deferasirox
- deferoxamine
- deflazacort
- denileukin diftitox
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- dexamethasone
- dexlansoprazole
- dexmedetomidine
- dexmedetomidine injection
- dexmethylphenidate
- dextroamphetamine
- diazoxide
- dichlorphenamide
- diclofenac
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- diethylpropion
- diflunisal
- digoxin
- dihydrocodeine
- dihydroergotamine
- dinutuximab
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- dofetilide
- doxapram
- doxazosin
- doxepin
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- dronabinol
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- duloxetine
- eletriptan
- emapalumab
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- enalapril
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- entacapone
- entrectinib
- enzalutamide
- ephedra
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- epinephrine
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- epoetin alfa
- epoprostenol
- erenumab
- ergocalciferol (vitamin D2)
- ergotamine
- ertugliflozin
- escitalopram
- esketamine
- eslicarbazepine acetate
- esomeprazole
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethacrynic acid
- ethanol
- ethinyl estradiol (contraceptive)
- etodolac
- etrasimod
- exenatide
- febuxostat
- fenfluramine
- fenoprofen
- fentanyl
- ferumoxytol
- fingolimod
- flaxseed
- flibanserin
- flucytosine
- fludrocortisone
- fluoxetine
- fluphenazine
- flurbiprofen
- fluvoxamine
- formoterol inhaled
- foscarnet
- fosinopril
- foslevodopa
- fostamatinib
- frovatriptan
- fruquintinib
- furosemide
- ganciclovir
- garlic
- gentamicin
- gilteritinib
- glimepiride
- glipizide
- glyburide
- guanfacine
- haloperidol
- hoodia
- hydralazine
- hydrocodone
- hydrocortisone
- hydromorphone
- ibrutinib
- ibuprofen
- ibuprofen lysine
- ifosfamide
- iloperidone
- iloprost
- iloprost inhaled
- imipramine
- immune globulin
- indomethacin
- insulin
- iohexol
- iopamidol
- irbesartan
- iron sucrose
- isoflurane
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- ketamine
- ketoprofen
- ketorolac
- landiolol
- lanreotide
- lansoprazole
- leflunomide
- lenalidomide
- lenvatinib
- levalbuterol inhaled
- levobunolol ophthalmic
- levodopa
- levomilnacipran
- levorphanol
- levothyroxine
- licorice
- lidocaine
- linagliptin
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lorlatinib
- losartan
- loxapine
- lubiprostone
- lumacaftor/ivacaftor
- lumateperone
- lurasidone
- luspatercept
- lutetium Lu 177 vipivotide tetraxetan
- magnesium citrate
- magnesium salicylate
- magnesium sulfate
- maraviroc
- meclofenamate
- mefenamic acid
- meloxicam
- meperidine
- mepivacaine
- mesalamine
- mesalamine rectal
- metformin
- methadone
- methamphetamine
- methazolamide
- methohexital
- methotrexate
- methoxy polyethylene glycol-epoetin beta
- methylene blue injection
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- midazolam
- midodrine
- mifepristone
- miglitol
- milnacipran
- milrinone
- mirabegron
- mirtazapine
- mitomycin
- modafinil
- moexipril
- molindone
- morphine
- motixafortide
- nabumetone
- nalbuphine
- naphazoline ophthalmic
- naproxen
- naratriptan
- nateglinide
- nattokinase
- naxitamab
- necitumumab
- neomycin
- niacin (vitamin B3)
- nilotinib
- niraparib
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- nortriptyline
- nusinersen
- obinutuzumab
- olanzapine
- oliceridine
- olmesartan medoxomil
- olodaterol inhaled
- olsalazine
- omeprazole
- opicapone
- opium
- osilodrostat
- oxaliplatin
- oxaprozin
- oxazepam
- oxcarbazepine
- oxycodone
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- oxytocin
- ozanimod
- paliperidone
- palopegteriparatide
- pamidronate
- panitumumab
- pantoprazole
- paricalcitol
- paromomycin
- paroxetine
- patiromer
- pazopanib
- pegloticase
- pemetrexed
- penicillamine
- pentamidine
- pentazocine
- pentobarbital
- pentostatin
- pentoxifylline
- perindopril
- perphenazine
- pexidartinib
- phendimetrazine
- phenelzine
- phenobarbital
- phentermine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- pioglitazone
- piroxicam
- plazomicin
- polyethylene glycol
- polyethylene glycol/electrolytes
- polymyxin B
- ponatinib
- ponesimod
- posaconazole
- pralsetinib
- pramipexole
- pramlintide
- prazosin
- prednisolone
- prednisone
- primidone
- probenecid
- procarbazine
- prochlorperazine
- promethazine
- propafenone
- propofol
- protriptyline
- pseudoephedrine
- quetiapine
- quinapril
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- rabeprazole
- ramipril
- ramucirumab
- rasagiline
- rasburicase
- regorafenib
- remifentanil
- remimazolam
- repaglinide
- Rho(D) immune globulin
- riociguat
- ripretinib
- risperidone
- rituximab
- rizatriptan
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine transdermal
- sacituzumab govitecan
- sacubitril
- safinamide
- salmeterol inhaled
- salsalate
- saxagliptin
- selegiline
- selegiline transdermal
- selinexor
- selpercatinib
- semaglutide
- sertraline
- sevoflurane
- sildenafil
- silodosin
- siponimod
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sodium benzoate
- sodium ferric gluconate complex
- sodium phenylacetate
- sodium phenylbutyrate
- sodium polystyrene sulfonate
- sodium thiosulfate
- sorafenib
- sotagliflozin
- sotalol
- sparsentan
- spironolactone
- streptomycin
- streptozocin
- sufentanil
- sulfate bowel prep
- sulindac
- sumatriptan
- sunitinib
- tacrolimus
- tadalafil
- tafasitamab
- tagraxofusp
- tamsulosin
- tapentadol
- taurine
- telavancin
- telmisartan
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- terazosin
- terbutaline
- teriflunomide
- teriparatide
- testosterone
- tetrahydrozoline ophthalmic
- thalidomide
- thioridazine
- thiothixene
- thyroid
- timolol ophthalmic
- tiopronin
- tirzepatide
- tivozanib
- tizanidine
- tobramycin
- tobramycin inhaled
- tolcapone
- tolmetin
- topiramate
- torsemide
- tramadol
- trametinib
- trandolapril
- tranylcypromine
- trastuzumab
- trazodone
- treprostinil
- triamcinolone
- triamterene
- trifluoperazine
- trimipramine
- vaccinia immune globulin
- vadadustat
- valacyclovir
- valganciclovir
- valsartan
- vamorolone
- vancomycin
- vandetanib
- vardenafil
- vasopressin
- venlafaxine
- vilanterol inhaled
- vilazodone
- viloxazine
- vitamin A (retinol)
- voclosporin
- vonoprazan
- vortioxetine
- vosoritide
- yohimbe
- ziprasidone
- ziv-aflibercept
- zoledronic acid
- zolmitriptan
- zonisamide
Caution Advised
- acitretin
- icosapent ethyl
- methoxsalen
- omega-3-acid
- verteporfin
Adverse Reactions .
Serious Reactions
- hypokalemia, severe
- electrolyte imbalance
- arrhythmia
- pancreatitis
- cholestatic jaundice
- anaphylaxis
- necrotizing angiitis
- erythema multiforme
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- exfoliative dermatitis
- photosensitivity
- renal failure
- interstitial nephritis
- aplastic anemia
- agranulocytosis
- leukopenia
- hemolytic anemia
- thrombocytopenia
Common Reactions
- hypokalemia
- hypochloremia
- hyponatremia
- hypomagnesemia
- hypercalcemia
- hyperuricemia
- hyperglycemia
- hyperlipidemia
- hypotension, orthostatic
- anorexia
- nausea
- vertigo
- constipation
- dizziness
- photosensitivity
- rash
- urticaria
- paresthesia
- headache
- muscle spasm
- weakness
- impotence
Safety/Monitoring .
Monitoring Parameters
BUN/Cr; electrolytes at baseline, then periodically
Look/Sound-Alike Drug Names
chlorthalidone confused with: chlorothiazide; chlorproMAZINE; clomiPRAMINE
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy if on chronic tx before conception, otherwise weigh risk/benefit; no known risk of teratogenicity based on human data; possible risk of decr. placental perfusion and neonatal adverse effects, incl. hypoglycemia, thrombocytopenia, and electrolyte abnormalities, based on limited or conflicting human data; risks not observed if chronic use before conception
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; possible risk of infant harm based on limited human data and drug properties; possible decr. milk production based on conflicting human data
Pharmacology .
Metabolism: liver; CYP450: unknown
Excretion: urine 50-75% (primarily unchanged); Half-life: 40-60h
Subclass: Diuretics, Thiazides
Mechanism of Action
inhibits distal convoluted tubule sodium and chloride reabsorption
Formulary .
No Formulary Selected
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