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Izervay
avacincaptad pegol intravitreal
Adult Dosing .
Dosage forms: INJ
geographic atrophy, age-related macular degeneration-associated
- [2 mg intravitreally qmo]
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- ocular infection
- periocular infection
- intraocular inflammation, active
Drug Interactions .
Overview
avacincaptad pegol
complement inhibitor
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- ocular infection
- periocular infection
- intraocular inflammation
- endophthalmitis
- retinal detachment
- age-related macular degeneration, neovascular
- optic ischemic neuropathy
Common Reactions
- conjunctival hemorrhage
- IOP incr.
- blurred vision
- age-related macular degeneration, neovascular
- ocular pain
- vitreous floaters
- blepharitis
Safety/Monitoring .
Monitoring Parameters
IOP (tonometry) prior to and immediately post-injection
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on minimal systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal maternal systemic absorption
Pharmacology .
Metabolism: catabolism; CYP450: unknown; Info: minimal systemic absorption
Excretion: urine; Half-life: 8 days
Subclass: Complement Inhibitors, Ophthalmic ; Macular Diseases
Mechanism of Action
inhibits complement protein C5, decreasing inflammasome and membrane attack complex (MAC) formation
Formulary .
No Formulary Selected
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