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Wainua
eplontersen
Adult Dosing .
Dosage forms: INJ (auto-injector): 45 mg
transthyretin amyloid polyneuropathy
- [45 mg SC qmo]
- Info: for pts w/ hereditary dz; vitamin A supplementation recommended
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
eplontersen
TTR protein synthesis inhibitor
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- AV block
Common Reactions
- serum vitamin A decr.
- vomiting
- proteinuria
- injection site rxn
- blurred vision
- cataract
- AV block
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at doses of up to 75 mg/kg
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver; CYP450: none
Excretion: urine (<1% unchanged); Half-life: 3wk
Subclass: Neuropathy/Neuralgia
Mechanism of Action
binds to transthyretin (TTR) mRNA, reducing serum TTR protein and deposits in tissues (antisense oligonucleotide)
Formulary .
No Formulary Selected
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