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Beyfortus (nirsevimab-alip)
nirsevimab (RSV-mAb)
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = nirsevimab-alip
RSV dz prevention
- [<34 wk gestation, <8 mo, <5 kg]
- Dose: 50 mg IM x1 dose; Start: before start of RSV season; Info: give <1 wk after birth if born during or entering RSV season; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass, see pkg insert; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules
- [<34 wk gestation, <8 mo, >5 kg]
- Dose: 100 mg IM x1 dose; Start: before start of RSV season; Info: give <1 wk after birth if born during or entering RSV season; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass, see pkg insert; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules
- [>34 wk gestation, <8 mo, <5 kg]
- Dose: 50 mg IM x1 dose; Start: before start of RSV season; Info: for infants born to unvaccinated mothers, born to mothers w/ unknown vaccine status, or born <14 days after maternal vaccination; give <1 wk after birth if born during or entering RSV season; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass, see pkg insert; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules
- [>34 wk gestation, <8 mo, >5 kg]
- Dose: 100 mg IM x1 dose; Start: before start of RSV season; Info: for infants born to unvaccinated mothers, born to mothers w/ unknown vaccine status, or born <14 days after maternal vaccination; give <1 wk after birth if born during or entering RSV season; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass, see pkg insert; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules
- [8-19 mo]
- Dose: 200 mg IM x1 dose; Start: before start of 2nd RSV season; Info: for pts at incr. risk for severe RSV dz, American Indian pts, and Alaska Native pts; consider additional dose if pt undergoing cardiac surgery w/ cardiopulmonary bypass, see pkg insert; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
nirsevimab
antiviral monoclonal antibody
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
Common Reactions
- injection site rxn
- rash
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
N/A; only indicated in pts <24 mo
Lactation
Clinical Summary
N/A; only indicated in pts <24 mo
Pharmacology .
Metabolism: other; CYP450: none
Excretion: other; Half-life: 71 days
Subclass: Respiratory Syncytial Virus (RSV) ; Routine Pediatric Vaccines
Mechanism of Action
binds to RSV F protein, inhibiting conformational changes necessary for viral fusion and entry
Formulary .
No Formulary Selected
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